1.I.1.1.2
Fungal Nuclear Pore Complex (NPC) with 29 components. Stuwe et al. 2015 presented
the reconstitution of the ~425-kilodalton inner ring
complex (IRC), which forms the central transport channel and diffusion
barrier of the NPC, revealing its interaction network and equimolar
stoichiometry. The Nsp1•Nup49•Nup57 channel nucleoporin heterotrimer
(CNT) attaches to the IRC solely through the adaptor nucleoporin Nic96.
The CNT•Nic96 structure reveals that Nic96 functions as an assembly
sensor that recognizes the three-dimensional architecture of the CNT,
thereby mediating the incorporation of a defined CNT state into the NPC.
They proposed that the IRC adopts a relatively rigid scaffold that
recruits the CNT to primarily form the diffusion barrier of the NPC,
rather than enabling channel dilation (Stuwe et al. 2015 presented
the reconstitution of the ~425-kilodalton inner ring
complex (IRC), which forms the central transport channel and diffusion
barrier of the NPC, revealing its interaction network and equimolar
stoichiometry. The Nsp1•Nup49•Nup57 channel nucleoporin heterotrimer
(CNT) attaches to the IRC solely through the adaptor nucleoporin Nic96.
The CNT•Nic96 structure reveals that Nic96 functions as an assembly
sensor that recognizes the three-dimensional architecture of the CNT,
thereby mediating the incorporation of a defined CNT state into the NPC.
They proposed that the IRC adopts a relatively rigid scaffold that
recruits the CNT to primarily form the diffusion barrier of the NPC,
rather than enabling channel dilation (Stuwe et al. 2015).
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| Accession Number: | G0SDP9 |
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| Protein Name: | Nucleoporin NUP152 |
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| Length: | 1463 |
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| Molecular Weight: | 152244.00 |
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| Species: | Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) [759272] |
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| Location1 / Topology2 / Orientation3: |
Nucleus1 |
|---|
| Substrate |
protein polypeptide chain, (ribonucleotide)n+m |
|---|
1: MDPPSKKRSI FGGITSLFRS STAPPEDRKG KSTNSNSVTA NAPSLPPPQP ESNGASSPFS
61: PAKRASEAQL SVRKIIPKPQ GPSSKLSQSV SASEIAHRPA PSTPAPAAAT PVPKRRPGDN
121: PHKLAASTST PALQNLPNPP APATSSKATS FSGAPSTPRP SIFRNSLYAR PAPATTYTQR
181: VSSHPLTQSF PPVTPGRPGR AANVDINNRI LSNTASTELF PMKIPEPPRH LTGEMLAKEV
241: PEDPNRAGSI YADEYLAHLC PPEFDDLQRR QFFCILDLRR LKYAADEVFL KKDWKINILN
301: FAKEYEKSRS LIMLRYGLYE FKTVRASEAV KREWKLKHGI PDSDDESGAP AKTNGGGKRK
361: AEEDLEPSSS TFTHTASPNK RARATEAPAT NKRKANDELE EESQPSKLQK PGSPSPAKTP
421: SATKSVFESI ANKTASPQTA PKSSLFSSST AAKPNGSIFD NAQKTPATSS NIFGHLSDAS
481: KDEDNESDTG SEAEAEDETP AKKKKKTTVN GASSSAPSEG GESTQSRSIF DRITRDANGQ
541: PVRQLPEGGL FSGESRKRSL SPVKELPANN TWNASAGIKF ATPGTSSIFG SSNPKPPATT
601: DTIDFAASTT KKPEEAAAPA EAPKEATPTT NLFGAQTKAT EEAPKPAATN IFGSTTNPTE
661: TSIPAGSLFS AKPATSTTNS LFGATTSAAG QKKDEESKPT EAAPAPAPAT STLFGAKPAT
721: TESPKTNLFQ FGTPNKTETA PATQPQFGGL FGKPPSTETP TEKPATTSLF GTDASKPATT
781: SSLFGSATTA ADKPAATNLF GSTTTPADKP TTTNLFGSTS TQATSGSDEP TAKKFAFGGT
841: TESKPTTSLF GSTTPAPATS TENKGGLFGA TTTSATPATN TKPLFGSTPA PAQENKPLFG
901: SSTTTAAPVF QFGSTPASTS TEQKPLFGAT AATDSKPLFG STSATSTEQK PLFGSSTTMT
961: EQKPLFGSIS TTATEQKPLF GSTSTTEAKP LFGAAPASTE QKSLFGITPS TTENNPASIF
1021: GNSSTSTEQK PLFGSAPAST EQKPLFGSTP STTENKPAGL FGNTSTTSTS TPLFNFGSQN
1081: TTASQPSTTG SIFGSASASF TFTAGGSDGT IKNPFASDGS YSAPTSFNFG SGDSQSSSAP
1141: FTFGAGGGTP SFTFGASSDS SNASNNASSA PIFSFGASQP SSTPLFGQNN PPAASNIFAS
1201: SLAPVGGTST GTSKHVPSFL ESENKASAYS SLDSPFTFGG ASSLATTPAA STPEPSAANA
1261: AAAGEDQGAS ADADEQPQEQ ISLTDGGPGE EDESVVHEVR AKAVKLVTAA DSSADSSNGS
1321: GEKPAEKKSN SPWKVMGVGP LRLLKHKQTG AVRMLLRAEP RGNIALNKLV LPQFTYKPDA
1381: ATPKFIKFAA ARDDGKGLET WMIQVKTPQL AQELAAALEE HKKANEKKDG EKNEESEKKD
1441: EKQEEKKNEE KKDEKEEKKD EKK