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|---|---|
| Accession Number: | O15234 |
| Protein Name: | Protein CASC3 aka MLN51 |
| Length: | 703 |
| Molecular Weight: | 76278.00 |
| Species: | Homo sapiens (Human) [9606] |
| Location1 / Topology2 / Orientation3: | Cytoplasm1 |
| Substrate | messenger RNA |
Cross database links:
| RefSeq: | NP_031385.2 |
|---|---|
| Entrez Gene ID: | 22794 |
| Pfam: | PF09405 |
| OMIM: |
606504 gene |
| KEGG: | hsa:22794 |
Gene Ontology
GO:0016607
C:nuclear speck
GO:0048471
C:perinuclear region of cytoplasm
GO:0042802
F:identical protein binding
GO:0003723
F:RNA binding
GO:0006397
P:mRNA processing
GO:0051028
P:mRNA transport
GO:0000184
P:nuclear-transcribed mRNA catabolic process,...
GO:0006417
P:regulation of translation
GO:0006950
P:response to stress
GO:0008380
P:RNA splicing
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References (18)[1] “Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.” Tomasetto C.L.et.al. 7490069 [2] “Metastatic lymph node 51, a novel nucleo-cytoplasmic protein overexpressed in breast cancer.” Degot S.F.et.al. 12080473 [3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [4] “DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.” Zody M.C.et.al. 16625196 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [6] “Targets of gene amplification and overexpression at 17q in gastric cancer.” Varis A.et.al. 11980659 [7] “Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module.” Degot S.et.al. 15166247 [8] “The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.” Ballut L.et.al. 16170325 [9] “Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.” Tange T.O.et.al. 16314458 [10] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.” Olsen J.V.et.al. 17081983 [11] “The exon-junction-complex-component metastatic lymph node 51 functions in stress-granule assembly.” Baguet A.et.al. 17652158 [12] “MLN51 stimulates the RNA-helicase activity of eIF4AIII.” Noble C.G.et.al. 17375189 [13] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 [14] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.” Gauci S.et.al. 19413330 | |
| Structure: | |
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MADRRRQRAS QDTEDEESGA SGSDSGGSPL RGGGSCSGSA GGGGSGSLPS QRGGRTGALH 61: LRRVESGGAK SAEESECESE DGIEGDAVLS DYESAEDSEG EEGEYSEEEN SKVELKSEAN 121: DAVNSSTKEE KGEEKPDTKS TVTGERQSGD GQESTEPVEN KVGKKGPKHL DDDEDRKNPA 181: YIPRKGLFFE HDLRGQTQEE EVRPKGRQRK LWKDEGRWEH DKFREDEQAP KSRQELIALY 241: GYDIRSAHNP DDIKPRRIRK PRYGSPPQRD PNWNGERLNK SHRHQGLGGT LPPRTFINRN 301: AAGTGRMSAP RNYSRSGGFK EGRAGFRPVE AGGQHGGRSG ETVKHEISYR SRRLEQTSVR 361: DPSPEADAPV LGSPEKEEAA SEPPAAAPDA APPPPDRPIE KKSYSRARRT RTKVGDAVKL 421: AEEVPPPPEG LIPAPPVPET TPTPPTKTGT WEAPVDSSTS GLEQDVAQLN IAEQNWSPGQ 481: PSFLQPRELR GMPNHIHMGA GPPPQFNRME EMGVQGGRAK RYSSQRQRPV PEPPAPPVHI 541: SIMEGHYYDP LQFQGPIYTH GDSPAPLPPQ GMLVQPGMNL PHPGLHPHQT PAPLPNPGLY 601: PPPVSMSPGQ PPPQQLLAPT YFSAPGVMNF GNPSYPYAPG ALPPPPPPHL YPNTQAPSQV 661: YGGVTYYNPA QQQVQPKPSP PRRTPQPVTI KPPPPEVVSR GSS