9.B.157.1.5 MreBCD cell shape-determining complex: Three proteins involved in Streptomyces coeicolor spore cell wall synthesis to form the thickened septum (relative to the vegegative cell wall). MreB is 342 aas long with possibly 1 TMS at about residue 180, a second protein, MreC, which is 366 residues long with possibly 3 TMSs, one N-terminal, one at about residue 160, and one at about residue 280, and MreD, which is 223 aas long and has 5 TMSs. This system has been characterized (Sigle et al. 2015; Vollmer et al. 2019). MreB gives a TC BLAST score of e-128; MreC gives a TC BLAST score of e-10, and MreD give a TC BLAST score of 0.0001 all with 9.B.157.1.4, showing that all 3 protein constituents are homology with other members of the family, but with greatly differing degrees of sequence similarities. MreD with 5 TMSs gives a TC BLAST score of 0.0004 with T# 3.A.1.28.2, suggesting a relationship with an ABC-type membrane transport protein.
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Accession Number: | O33621 |
Protein Name: | MreD protein |
Length: | 223 |
Molecular Weight: | 22762.00 |
Species: | Streptomyces coelicolor [1902] |
Number of TMSs: | 5 |
Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
Substrate |
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1: MRVNRILLSV ALVVVALVIQ VSVLARLHLP GAVPDLLLLT VLGLALVYGH VGGALVGFGA
61: GLLADLAPPA DHAAGRYALV LCVIGYLAGL ARPDNGRLRS ATGPMVVVVA AAVGTTLLYA
121: GVGALVGDTA ARHVGLPSLL FTAALYDLLL APFVVPGIMA LARRAEHDPL ADTNSAAQSP
181: DISSGWLSSG TGLRIGRTGN ALRVKTARAR VARAGRIKGV KRL