8.A.23.1.39
Receptor tyrosine-protein kinase ErbB-2/ErbB-3. ErbB-2 is also called ERBB2, HER2, MLN19, NEU and NGL. It is of 1255 aas and possibly 2 TMSs, one at the N-terminus, and one large hydrophobic peak in the C-terminal half of the protein. ErbB-3 is also called HER3 and is of 1342 aas with at least one TMS near residue 650, but maybe also an N-terminal TMS. These two proteins form a complex with SorLA (TC# 9.B.87.1.17) (Al-Akhrass et al. 2021). They are parts of several cell surface receptor
complexes that apparently need a coreceptor for ligand binding. They are essential components of a neuregulin-receptor complex (Ieguchi et al. 2010). Expression profiling has identified TRPM7 and HER2 as potential targets for the combined treatment of cancer cells (Egawa et al. 2024). Other protein constituents of this ErbB2 signalling complex may include PMCA2 or ATP2B2 (TC# 3.a.3.2.40), Ezrin (TC# 8.A.25.1.1), Erbin (LAP2; Q96RT1; 1412 aas) and NHERF1 or NHE-RF1 (SLC9A3R1), TC# 8.A.24.1.1).
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| Accession Number: | P04626 |
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| Protein Name: | Receptor tyrosine-protein kinase erbB-2 |
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| Length: | 1255 |
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| Molecular Weight: | 137910.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 3 |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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1: MELAALCRWG LLLALLPPGA ASTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL
61: ELTYLPTNAS LSFLQDIQEV QGYVLIAHNQ VRQVPLQRLR IVRGTQLFED NYALAVLDNG
121: DPLNNTTPVT GASPGGLREL QLRSLTEILK GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA
181: LTLIDTNRSR ACHPCSPMCK GSRCWGESSE DCQSLTRTVC AGGCARCKGP LPTDCCHEQC
241: AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTACP
301: YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL REVRAVTSAN
361: IQEFAGCKKI FGSLAFLPES FDGDPASNTA PLQPEQLQVF ETLEEITGYL YISAWPDSLP
421: DLSVFQNLQV IRGRILHNGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHH NTHLCFVHTV
481: PWDQLFRNPH QALLHTANRP EDECVGEGLA CHQLCARGHC WGPGPTQCVN CSQFLRGQEC
541: VEECRVLQGL PREYVNARHC LPCHPECQPQ NGSVTCFGPE ADQCVACAHY KDPPFCVARC
601: PSGVKPDLSY MPIWKFPDEE GACQPCPINC THSCVDLDDK GCPAEQRASP LTSIISAVVG
661: ILLVVVLGVV FGILIKRRQQ KIRKYTMRRL LQETELVEPL TPSGAMPNQA QMRILKETEL
721: RKVKVLGSGA FGTVYKGIWI PDGENVKIPV AIKVLRENTS PKANKEILDE AYVMAGVGSP
781: YVSRLLGICL TSTVQLVTQL MPYGCLLDHV RENRGRLGSQ DLLNWCMQIA KGMSYLEDVR
841: LVHRDLAARN VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILRRRFT
901: HQSDVWSYGV TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID VYMIMVKCWM
961: IDSECRPRFR ELVSEFSRMA RDPQRFVVIQ NEDLGPASPL DSTFYRSLLE DDDMGDLVDA
1021: EEYLVPQQGF FCPDPAPGAG GMVHHRHRSS STRSGGGDLT LGLEPSEEEA PRSPLAPSEG
1081: AGSDVFDGDL GMGAAKGLQS LPTHDPSPLQ RYSEDPTVPL PSETDGYVAP LTCSPQPEYV
1141: NQPDVRPQPP SPREGPLPAA RPAGATLERP KTLSPGKNGV VKDVFAFGGA VENPEYLTPQ
1201: GGAAPQPHPP PAFSPAFDNL YYWDQDPPER GAPPSTFKGT PTAENPEYLG LDVPV