TCDB is operated by the Saier Lab Bioinformatics Group

8.A.23 The Basigin (Basigin) Family

Basigin precursor protein of humans is also called CD147, 5F7, emmprin, leukocyte activation antigen, MP, (tumor-derived) collagenase stimulating factor, and extracellular matrix metalloproteinase inhibitor. It is a chaperone glycoprotein with an N-terminal leader peptide that is probably removed by proteolysis after secretion. It has a second TMS near its C-terminus. Additionally, it has two IGcan immunoglobulin-like cell adhesion domains (positions 20-110 and 220-310). The protein directs transporters such as MCT1, MCT2. MCT3 amd MCT4 but not MCT8 (2.A.1.13) to the plasma membrane and remains bound to them, being required for activity and for sensitivity to inhibition by organomercurials (Wilson et al., 2005; Halestrap 2013).  It appears to regulate complex I activity and apoptosis in mitochondria by interacting with mitochondrial NDUFS6 (Luo et al. 2014).  It has many homologues in vertebrate and invertebrate animals, and several of these have been functionaly characterized. The role of basigin in regulating many transporters has been reviewed (Muramatsu 2016). The basigin Ig-I domain mediates interactions with monocarboxylate transporters (MCTs, TC# 2.A.1.13) which are required for the transporter to reach the plasma membrane during biogenesis and also affects the activities of these transporters (Köpnick et al. 2021). Plasmodium yoelii erythrocyte binding like protein interacts with basigin, an erythrocyte surface protein (Yuguchi et al. 2021).

Basigin is the receptor for cyclophilins, S100A9, and platelet GPVI, while basigin-1 serves as the receptor for the rod-derived cone viability factor (Muramatsu 2015). As noted above, basigin tightly associates with monocarboxylate transporters, and is essential for their cell surface translocation and activities, but  it also associates with other proteins including GLUT1, CD44, and CD98. The carbohydrate portion is recognized by lectins, such as galectin-3 and E-selectin. These molecular recognitions form the basis for the role of basigin in the transport of nutrients, migration of inflammatory leukocytes, and induction of matrix metalloproteinases. Basigin is important in vision, spermatogenesis, and other physiological phenomena, and plays roles in the pathogenesis of numerous diseases, including cancer. It is also the receptor for an invasive protein RH5, which is present in malaria parasites. Loss of Basigin expression in uterine cells leads to subfertility in female mice (Li et al. 2021).  Full activation of thermogenesis in brown adipocytes requires Basigin action (Rupar et al. 2023).   Basigin mediation of Plasmodium falciparum red blood cell invasion does not require its transmembrane domain or interaction with monocarboxylate transporter 1 (King et al. 2024).  CD147/Basigin is involved in the development of malignant tumors and T-cell-mediated immunological disorders via glycolysis regulation (Kanekura 2023).

Contactin 2, a glycosylphosphatidylinositol-anchored neuronal membrane protein, and another transmembrane protein called contactin associated protein-like 2 (CNTNAP2 alias CASPR2) are together necessary to maintain voltage-gated potassium channels at the juxtaparanodal region. CNTN2 knockout mice were previously reported to suffer from spontaneous seizures and mutations in the CNTNAP2 gene have been described to cause myoclonic tremor and epilepsy in humans (Stogmann et al. 2013).

The rat liver C-BAT is a 110 kDa glycoprotein (GP110) of 519 amino acids. Its short C-terminus is in the cytoplasm, it spans the membrane once, and the majority of the protein is external. It contains the ATP-binding consensus site (residues 92-100) of GPAYSGRET and is an ecto-ATPase. Transfection of heterologous cells with the cDNA encoding this protein conferred both bile acid transport and ecto-ATPase activity to the recipient cells (Sippel et al. 1993; 1994). Taurocholate is pumped out of the cell. Transport (but not ATPase activity) appears to be stimulated by protein kinase C-mediated phosphorylation of the C-terminal domain. The ecto-ATPase activity of this protein does not appear to mediate transport although reduction in the cytoplasmic ATP concentration reduces the transport rate. Both ATP and the membrane potential have been implicated as energy sources for transport.

The topology of the rat liver C-BAT protein as a Type I membrane protein, the dissection of its transport activity from its ecto-ATPase activity, its homology to members of the carcinogenic antigen superfamily and its identification as a calcium-independent cell adhesin in the apical membrane of the hepatocyte all suggest that this protein does not alone function as a bile acid efflux pump (Suchy et al. 1997). The involvement of at least one other protein is suggested, and this other protein may be the primary bile acid export permease. GP110 may thus be an accessory protein, possibly an activator that is responsive to protein kinase (Halestrap 2013).  CD147/Basigin Is involved in the development of malignant tumors and T-cell mediated immunological disorders via regulation of glycolysis (Kanekura 2023).

Neuroplastins are homologous to and function like basigins. Of these, both np65 and np55 induce neurite outgrowth, and both activate the FGF receptor and associated downstream signalling pathways. Np65 binds to and colocalises with GABA(A) receptor subtypes (TC # 1.A.9) and may play a role in anchoring them to specific synaptic and extrasynaptic sites. The neuroplastins have been shown to chaperone and support the monocarboxylate transporter MCT2 in transporting lactate across the neuronal plasma membrane. The neuroplastins are multifunctional adhesins that support neurite outgrowth, modulate long-term activity-dependent synaptic plasticity, regulate surface expression of GluR1 receptors, modulate GABA(A) receptor localisation, and play a key role in delivery of monocarboxylate energy substrates both to the synapse and to extrasynaptic sites (Beesley et al. 2014). 

Viral entry into the host cell is the first step towards successful infection. Viral entry starts with virion attachment, and binding to receptors. Receptor binding viruses either directly release their genomes into the cell, or enter cells through endocytosis. For DNA viruses and a few RNA viruses, the endocytosed viruses is transported from cytoplasm into the nucleus followed by gene expression. The receptor for infection by white spot syndrome virus (WSSV) for kuruma shrimp, Marsupenaeus japonicus, is a member of the immunoglobulin superfamily (IgSF) with a transmembrane region, and is similar to the vertebrate polymeric immunoglobulin receptor (pIgR). MjpIgR was detected in all tissues tested, and its expression was induced by WSSV infection. Knockdown of MjpIgR, and blocking MjpIgR with its antibody inhibited WSSV infection, and overexpression facilitated the invasion. The extracellular domain of MjpIgR interacts with envelope protein VP24 of WSSV and the intracellular domain interacts with calmodulin (MjCaM). MjpIgR oligomerizes and is internalized by clathrin-dependent endocytosis (Niu et al. 2019).

CD4 is an integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses to both external and internal stimuli. In T-cells,  it functions primarily as a coreceptor for MHC class II molecule:peptide complex (Doyle and Strominger 2006). The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. CD4 interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen-presenting cells (APCs) (Bernstein et al. 2006). In turn, it recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates, ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, it plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway (Zhen et al. 2014) while participating in the development of T-helper cells in the thymus and triggering the differentiation of monocytes into functional mature macrophages (Zhen et al. 2014).  It is the primary receptor for human immunodeficiency virus-1 (HIV-1) (Crise et al. 1990, Sharma et al. 2005, Matthias et al. 2002). It is down-regulated by HIV-1 Vpu (Lindwasser et al. 2007) and acts as a receptor for human Herpes virus 7/HHV-7 (Lusso et al. 1994). CD4 and its co-receptor, CCR5, exist in the membrane in a fluid state that may be essential for membrane fusion between the viral envelop and the cell membrane (Matthias et al. 2002).

Ephrin-B1 is one of the critical components of the slit diaphragm of kidney glomerular podocytes. Ephrin-B1-associated molecules were studied (Fukusumi et al. 2021). Na+/H+ exchanger regulatory factor 2 (NHERF2), a scaffolding protein, is associated with ephrin-B1. NHERF2 was expressed in the apical area and the slit diaphragm, and it interacted with the nephrin-ephrin-B1 complex at the slit diaphragm. The nephrin-ephrin-B1-NHERF2 complex interacted with ezrin bound to F-actin. NHERF2 bound ephrin-B1 via its first postsynaptic density protein-95/disks large/zonula occludens-1 domain, and podocalyxin via its second postsynaptic density protein-95/disks large/zonula occludens-1 domain. Phosphorylation of nephrin and ephrin-B1, and dephosphorylation of NHERF2 and ezrin, disrupted the linkages of ephrin-B1-NHERF2 and NHERF2-ezrin (Fukusumi et al. 2021).

Interactions between the polysialylated neural cell adhesion molecule (TC# 8.A.23.1.49) and the transient receptor potential canonical channels TrpC1, 4, and 5 induce entry of Ca2+ into neurons (Amores-Bonet et al. 2022). NCAMs play roles in the developing and mature nervous systems. Amores-Bonet et al. 2022 showed that the transient receptor potential canonical (TRPC) ion channels TRPC1, -4, and -5 not only interact with the intracellular domains of the transmembrane isoforms NCAM140 and NCAM180, but also with the glycan polysialic acid (PSA) covalently attached to the NCAM protein backbone. NCAM antibody treatment leads to the opening of TRPC1, -4, and -5 hetero- or homomers at the plasma membrane and to the influx of Ca2+ into cultured cortical neurons and CHO cells expressing NCAM, PSA, and TRPC1 and -4 or TRPC1 and -5. NCAM-stimulated Ca2+ entry was blocked by the TRPC inhibitor Pico145 or the bacterial PSA homolog colominic acid. NCAM-stimulated Ca2+ influx was detectable neither in NCAM-deficient cortical neurons nor in TRPC1/4- or TRPC1/5-expressing CHO cells that express NCAM, but not PSA. NCAM-induced neurite outgrowth was reduced by TRPC inhibitors and a function-blocking TRPC1 antibody. A characteristic signaling feature was that extracellular signal-regulated kinase 1/2 phosphorylation was also reduced by TRPC inhibitors. This indicates that the interaction of NCAM with TRPC1, -4, and -5 contributes to the NCAM-stimulated and PSA-dependent Ca2+ entry into neurons, thereby influencing essential neural functions (Amores-Bonet et al. 2022).



This family belongs to the: Basigin-Tapasin-TREM2/PIGR Superfamily.

References associated with 8.A.23 family:

Al-Akhrass, H., J.R.W. Conway, A.S.A. Poulsen, I. Paatero, J. Kaivola, A. Padzik, O.M. Andersen, and J. Ivaska. (2021). A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance. Oncogene 40: 1300-1317. 33420373
Amores-Bonet, L., R. Kleene, T. Theis, and M. Schachner. (2022). Interactions between the Polysialylated Neural Cell Adhesion Molecule and the Transient Receptor Potential Canonical Channels 1, 4, and 5 Induce Entry of Ca into Neuron.s. Int J Mol Sci 23:. 36077460
An, B., A. Ando, H. Akuta, F. Morishita, and T. Imamura. (2023). Human-biased TMEM25 expression promotes expansion of neural progenitor cells to alter cortical structure in the developing brain. FEBS Lett. [Epub: Ahead of Print] 37846797
Anfosso, F., N. Bardin, E. Vivier, F. Sabatier, J. Sampol, and F. Dignat-George. (2001). Outside-in signaling pathway linked to CD146 engagement in human endothelial cells. J. Biol. Chem. 276: 1564-1569. 11036077
Bailly, C., X. Thuru, and B. Quesnel. (2021). Soluble Programmed Death Ligand-1 (sPD-L1): A Pool of Circulating Proteins Implicated in Health and Diseases. Cancers (Basel) 13:. 34204509
Bartoszewski, S., S. Luschnig, I. Desjeux, J. Grosshans, and C. Nüsslein-Volhard. (2004). Drosophila p24 homologues eclair and baiser are necessary for the activity of the maternally expressed Tkv receptor during early embryogenesis. Mech Dev 121: 1259-1273. 15327786
Beesley, P., M. Kraus, and N. Parolaro. (2014). The neuroplastins: multifunctional neuronal adhesion molecules--involvement in behaviour and disease. Adv Neurobiol 8: 61-89. 25300133
Ben Mkaddem, S., M. Aloulou, M. Benhamou, and R.C. Monteiro. (2014). Role of FcγRIIIA (CD16) in IVIg-mediated anti-inflammatory function. J Clin Immunol 34Suppl1: S46-50. 24728843
Bernstein, H.B., M.C. Plasterer, S.E. Schiff, C.M. Kitchen, S. Kitchen, and J.A. Zack. (2006). CD4 expression on activated NK cells: ligation of CD4 induces cytokine expression and cell migration. J Immunol 177: 3669-3676. 16951326
Bi, J., Z. Wu, X. Zhang, T. Zeng, W. Dai, N. Qiu, M. Xu, Y. Qiao, L. Ke, J. Zhao, X. Cao, Q. Lin, X.L. Chen, L. Xie, Z. Ouyang, J. Guo, L. Zheng, C. Ma, S. Guo, K. Chen, W. Mo, G. Fu, T.J. Zhao, and H.R. Wang. (2023). TMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal state to suppress triple-negative breast cancer progression. Nat Commun 14: 2342. 37095176
Burr, M.L., C.E. Sparbier, Y.C. Chan, J.C. Williamson, K. Woods, P.A. Beavis, E.Y.N. Lam, M.A. Henderson, C.C. Bell, S. Stolzenburg, O. Gilan, S. Bloor, T. Noori, D.W. Morgens, M.C. Bassik, P.J. Neeson, A. Behren, P.K. Darcy, S.J. Dawson, I. Voskoboinik, J.A. Trapani, J. Cebon, P.J. Lehner, and M.A. Dawson. (2017). CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity. Nature 549: 101-105. 28813417
Cai, K., X. Zhang, and X.C. Bai. (2022). Cryo-electron Microscopic Analysis of Single-Pass Transmembrane Receptors. Chem Rev. [Epub: Ahead of Print] 35715229
Capdevila-Nortes X., Jeworutzki E., Elorza-Vidal X., Barrallo-Gimeno A., Pusch M. and Estevez R. (2015). Structural determinants of interaction, trafficking and function in the ClC-2/MLC1 subunit GlialCAM involved in leukodystrophy. J Physiol. 593(18):4165-80. 26033718
Chang, X., Y.H. Song, T. Xia, Z.X. He, S.B. Zhao, Z.J. Wang, L. Gu, Z.S. Li, C. Xu, S.L. Wang, and Y. Bai. (2023). Macrophage-derived exosomes promote intestinal mucosal barrier dysfunction in inflammatory bowel disease by regulating TMIGD1 via mircroRNA-223. Int Immunopharmacol 121: 110447. [Epub: Ahead of Print] 37301121
Chen, D., P.W. Li, B.A. Goldstein, W. Cai, E.L. Thomas, F. Chen, A.E. Hubbard, S. Melov, and P. Kapahi. (2013). Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell Rep 5: 1600-1610. 24332851
Cho, H.J., J. Yu, C. Xie, P. Rudrabhatla, X. Chen, J. Wu, L. Parisiadou, G. Liu, L. Sun, B. Ma, J. Ding, Z. Liu, and H. Cai. (2014). Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export. EMBO. J. 33: 2314-2331. 25201882
Cohen, C.J., J.T. Shieh, R.J. Pickles, T. Okegawa, J.T. Hsieh, and J.M. Bergelson. (2001). The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction. Proc. Natl. Acad. Sci. USA 98: 15191-15196. 11734628
Crise, B., L. Buonocore, and J.K. Rose. (1990). CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor. J. Virol. 64: 5585-5593. 2214026
Dascalu, A.E., C. Furman, I. Landrieu, F.X. Cantrelle, J. Mortelecque, G. Grolaux, P. Gillery, F. Tessier, E. Lipka, M. Billamboz, E. Boulanger, and A. Ghinet. (2024). Development of Receptor for Advanced Glycation End Products (RAGE) ligands through target directed dynamic combinatorial chemistry: a novel class of possible antagonists. Chemistry 30: e202303255. 38317623
Dietrich, J., M. Cella, M. Seiffert, H.J. Bühring, and M. Colonna. (2000). Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells. J Immunol 164: 9-12. 10604985
Doyle, C. and J.L. Strominger. (2006). Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature 330: 256-259. 2823150
Erber, R., U. Eichelsbacher, V. Powajbo, T. Korn, V. Djonov, J. Lin, H.P. Hammes, R. Grobholz, A. Ullrich, and P. Vajkoczy. (2006). EphB4 controls blood vascular morphogenesis during postnatal angiogenesis. EMBO. J. 25: 628-641. 16424904
Fang, F., L.F. Lue, S. Yan, H. Xu, J.S. Luddy, D. Chen, D.G. Walker, D.M. Stern, S. Yan, A.M. Schmidt, J.X. Chen, and S.S. Yan. (2010). RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer''s disease. FASEB J. 24: 1043-1055. 19906677
Ferrara, C., S. Grau, C. Jäger, P. Sondermann, P. Brünker, I. Waldhauer, M. Hennig, A. Ruf, A.C. Rufer, M. Stihle, P. Umaña, and J. Benz. (2011). Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose. Proc. Natl. Acad. Sci. USA 108: 12669-12674. 21768335
Fierro-González, J.C., M. González-Barrios, A. Miranda-Vizuete, and P. Swoboda. (2011). The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans. Biochem. Biophys. Res. Commun. 406: 478-482. 21334311
Freeman, G.J., A.J. Long, Y. Iwai, K. Bourque, T. Chernova, H. Nishimura, L.J. Fitz, N. Malenkovich, T. Okazaki, M.C. Byrne, H.F. Horton, L. Fouser, L. Carter, V. Ling, M.R. Bowman, B.M. Carreno, M. Collins, C.R. Wood, and T. Honjo. (2000). Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 192: 1027-1034. 11015443
Fukusumi, Y., H. Yasuda, Y. Zhang, and H. Kawachi. (2021). Nephrin-Ephrin-B1-Na/H Exchanger Regulatory Factor 2-Ezrin-Actin Axis Is Critical in Podocyte Injury. Am J Pathol 191: 1209-1226. 33887216
Gao, Y., D. Zhang, F. Wang, D. Zhang, P. Li, and K. Wang. (2022). BRAF V600E protect from cell death via inhibition of the mitochondrial permeability transition in papillary and anaplastic thyroid cancers. J Cell Mol Med 26: 4048-4060. 35748101
Geiger, J.A., L. Carvalho, I. Campos, A.C. Santos, and A. Jacinto. (2011). Hole-in-one mutant phenotypes link EGFR/ERK signaling to epithelial tissue repair in Drosophila. PLoS One 6: e28349. 22140578
Giepmans, B.N. (2006). Role of connexin43-interacting proteins at gap junctions. Adv Cardiol 42: 41-56. 16646583
Gómez-Suaga, P., B. Luzón-Toro, D. Churamani, L. Zhang, D. Bloor-Young, S. Patel, P.G. Woodman, G.C. Churchill, and S. Hilfiker. (2012). Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP. Hum Mol Genet 21: 511-525. 22012985
González-Cabrero, J., C.J. Wise, Y. Latchman, G.J. Freeman, A.H. Sharpe, and H. Reiser. (1999). CD48-deficient mice have a pronounced defect in CD4(+) T cell activation. Proc. Natl. Acad. Sci. USA 96: 1019-1023. 9927686
Griewank, K., C. Borowski, S. Rietdijk, N. Wang, A. Julien, D.G. Wei, A.A. Mamchak, C. Terhorst, and A. Bendelac. (2007). Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. Immunity 27: 751-762. 18031695
Griffin, J.H., J. Leung, R.J. Bruner, M.A. Caligiuri, and R. Briesewitz. (2003). Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome. Proc. Natl. Acad. Sci. USA 100: 7830-7835. 12808148
Guo, L., D.R. Bertola, A. Takanohashi, A. Saito, Y. Segawa, T. Yokota, S. Ishibashi, Y. Nishida, G.L. Yamamoto, J.F.D.S. Franco, R.S. Honjo, C.A. Kim, C.M. Musso, M. Timmons, A. Pizzino, R.J. Taft, B. Lajoie, M.A. Knight, K.H. Fischbeck, A.B. Singleton, C.R. Ferreira, Z. Wang, L. Yan, J.Y. Garbern, P.O. Simsek-Kiper, H. Ohashi, P.G. Robey, A. Boyde, N. Matsumoto, N. Miyake, J. Spranger, R. Schiffmann, A. Vanderver, G. Nishimura, M.R.D.S. Passos-Bueno, C. Simons, K. Ishikawa, and S. Ikegawa. (2019). Bi-allelic CSF1R Mutations Cause Skeletal Dysplasia of Dysosteosclerosis-Pyle Disease Spectrum and Degenerative Encephalopathy with Brain Malformation. Am J Hum Genet 104: 925-935. 30982609
Haenzi, B. and L.D. Moon. (2017). The Function of FGFR1 Signalling in the Spinal Cord: Therapeutic Approaches Using FGFR1 Ligands after Spinal Cord Injury. Neural Plast 2017: 2740768. 28197342
Halestrap, A.P. (2012). The monocarboxylate transporter family--Structure and functional characterization. IUBMB Life 64: 1-9. 22131303
Halestrap, A.P. (2013). The SLC16 gene family - structure, role and regulation in health and disease. Mol Aspects Med 34: 337-349. 23506875
Haniu, M., J. Talvenheimo, J. Le, V. Katta, A. Welcher, and M.F. Rohde. (1995). Extracellular domain of neurotrophin receptor trkB: disulfide structure, N-glycosylation sites, and ligand binding. Arch Biochem Biophys 322: 256-264. 7574684
Hayashi, A., H. Ohnishi, H. Okazawa, S. Nakazawa, H. Ikeda, S. Motegi, N. Aoki, S. Kimura, M. Mikuni, and T. Matozaki. (2004). Positive regulation of phagocytosis by SIRPbeta and its signaling mechanism in macrophages. J. Biol. Chem. 279: 29450-29460. 15123631
Hayashi, T., T. Takahashi, S. Motoya, T. Ishida, F. Itoh, M. Adachi, Y. Hinoda, and K. Imai. (2001). MUC1 mucin core protein binds to the domain 1 of ICAM-1. Digestion 63Suppl1: 87-92. 11173916
Hoorn, E.J. and J.H.F. de Baaij. (2022). Chloride-sensitive signaling turns the potassium switch on. Kidney Int 102: 956-958. 36272750
Hu, M.C., M. Shi, and O.W. Moe. (2018). Role of αKlotho and FGF23 in regulation of type II Na-dependent phosphate co-transporters. Pflugers Arch. [Epub: Ahead of Print] 30506274
Huang, Y.A., B. Zhou, M. Wernig, and T.C. Südhof. (2017). ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion. Cell 168: 427-441.e21. 28111074
Ieguchi, K., M. Fujita, Z. Ma, P. Davari, Y. Taniguchi, K. Sekiguchi, B. Wang, Y.K. Takada, and Y. Takada. (2010). Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling. J. Biol. Chem. 285: 31388-31398. 20682778
Ifie, E., M.A. Russell, S. Dhayal, P. Leete, G. Sebastiani, L. Nigi, F. Dotta, V. Marjomäki, D.L. Eizirik, N.G. Morgan, and S.J. Richardson. (2018). Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells. Diabetologia. [Epub: Ahead of Print] 30074059
Irmer, B., J. Efing, L.E. Reitnauer, A. Angenendt, S. Heinrichs, A. Schubert, M. Schulz, C. Binder, J. Tio, U. Hansen, C. Geyer, M. Gerwing, A. Bleckmann, and K. Menck. (2023). Extracellular vesicle-associated tyrosine kinase-like orphan receptors ROR1 and ROR2 promote breast cancer progression. Cell Commun Signal 21: 171. 37430307
Jiang, H., X. Zhang, Y. Wu, B. Zhang, J. Wei, J. Li, Y. Huang, L. Chen, and X. He. (2022). Bioinformatics identification and validation of biomarkers and infiltrating immune cells in endometriosis. Front Immunol 13: 944683. 36524127
Jin, Q., H. Chen, A. Luo, F. Ding, and Z. Liu. (2011). S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE). PLoS One 6: e19375. 21559403
Johnson, J.P., U. Rothbächer, and C. Sers. (1993). The progression associated antigen MUC18: a unique member of the immunoglobulin supergene family. Melanoma Res 3: 337-340. 8292890
Kamakura, S., J. Hayase, A. Kohda, Y. Iwakiri, K. Chishiki, T. Izaki, and H. Sumimoto. (2024). TMEM25 is a Par3-binding protein that attenuates claudin assembly during tight junction development. EMBO Rep 25: 144-167. 38177906
Kanekura, T. (2023). CD147/Basigin Is Involved in the Development of Malignant Tumors and T-Cell-Mediated Immunological Disorders via Regulation of Glycolysis. Int J Mol Sci 24:. 38139173
Kazlauskas, A., D.L. Durden, and J.A. Cooper. (1991). Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit. Cell Regul 2: 413-425. 1653029
Kelly, J.D., B.A. Haldeman, F.J. Grant, M.J. Murray, R.A. Seifert, D.F. Bowen-Pope, J.A. Cooper, and A. Kazlauskas. (1991). Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation. J. Biol. Chem. 266: 8987-8992. 1709159
Kendrick, A.A., J. Schafer, M. Dzieciatkowska, T. Nemkov, A.D. Alessandro, D. Neelakantan, H.L. Ford, C.G. Pearson, C.D. Weekes, K.C. Hansen, and E.Z. Eisenmesser. (2016). CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming. Oncotarget. [Epub: Ahead of Print] 28039486
King, N.R., C. Martins Freire, J. Touhami, M. Sitbon, A.M. Toye, and T.J. Satchwell. (2024). Basigin mediation of  Plasmodium falciparum red blood cell invasion does not require its transmembrane domain or interaction with monocarboxylate transporter 1. PLoS Pathog 20: e1011989. [Epub: Ahead of Print] 38315723
Köpnick, A.L., A. Jansen, K. Geistlinger, N.H. Epalle, and E. Beitz. (2021). Basigin drives intracellular accumulation of l-lactate by harvesting protons and substrate anions. PLoS One 16: e0249110. 33770122
Koppel, N., M.B. Friese, H.L. Cardasis, T.A. Neubert, and S.J. Burden. (2019). Vezatin is required for the maturation of the neuromuscular synapse. Mol. Biol. Cell 30: 2571-2583. 31411944
Lehman, S.L., G.J. Cerniglia, G.J. Johannes, J. Ye, S. Ryeom, and C. Koumenis. (2015). Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress. PLoS Genet 11: e1005212. 26102367
Li, H., L. Yang, Y. Sun, Y. Zhang, J. Chai, B. Liu, and Y. Ye. (2021). Silencing of CD147 inhibits hepatic stellate cells activation related to suppressing aerobic glycolysis via hedgehog signaling. Cytotechnology 73: 233-242. 33927478
Li, K., Q. Li, S.T. Bashir, B.M. Bany, and R.A. Nowak. (2021). Loss of Basigin expression in uterine cells leads to subfertility in female mice. Biol Reprod. [Epub: Ahead of Print] 34106247
Li, Y., J. Zhang, Y. Cai, H. Liu, W. Yang, Y. Xu, and M. Huang. (2023). VSTM2L contributes to anoikis resistance and acts as a novel biomarker for metastasis and clinical outcome in ovarian cancer. Biochem. Biophys. Res. Commun. 658: 107-115. 37030064
Lin, X., M.G.K. Brunk, P. Yuanxiang, A.W. Curran, E. Zhang, F. Stöber, J. Goldschmidt, E.D. Gundelfinger, M. Vollmer, M.F.K. Happel, R. Herrera-Molina, and D. Montag. (2021). Neuroplastin expression is essential for hearing and hair cell PMCA expression. Brain Struct Funct 226: 1533-1551. 33844052
Lindwasser, O.W., R. Chaudhuri, and J.S. Bonifacino. (2007). Mechanisms of CD4 downregulation by the Nef and Vpu proteins of primate immunodeficiency viruses. Curr Mol Med 7: 171-184. 17346169
Loers, G., R. Kleene, V. Granato, U. Bork, and M. Schachner. (2023). Interaction of L1CAM with LC3 Is Required for L1-Dependent Neurite Outgrowth and Survival. Int J Mol Sci 24:. 37569906
Luo, Z., W. Zeng, W. Tang, T. Long, J. Zhang, X. Xie, Y. Kuang, M. Chen, J. Su, and X. Chen. (2014). CD147 interacts with NDUFS6 in regulating mitochondrial complex I activity and the mitochondrial apoptotic pathway in human malignant melanoma cells. Curr Mol Med 14: 1252-1264. 25470292
Lusso, P., P. Secchiero, R.W. Crowley, A. Garzino-Demo, Z.N. Berneman, and R.C. Gallo. (1994). CD4 is a critical component of the receptor for human herpesvirus 7: interference with human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 91: 3872-3876. 7909607
Lv, J., W. Ge, Z. Ding, J. Zeng, W. Wang, H. Duan, Y. Zhang, X. Zhao, and J. Hu. (2022). Regulatory role of dihydrotestosterone on BMP-6 receptors in granular cells of sheep antral follicles. Gene 810: 146066. 34838638
Martin, T.M., S.J. Burke, C.H. Wasserfall, and J.J. Collier. (2023). Islet β-cells and intercellular adhesion molecule-1 (ICAM-1): Integrating immune responses that influence autoimmunity and graft rejection. Autoimmun Rev 22: 103414. [Epub: Ahead of Print] 37619906
Martin-Almedina, S., I. Martinez-Corral, R. Holdhus, A. Vicente, E. Fotiou, S. Lin, K. Petersen, M.A. Simpson, A. Hoischen, C. Gilissen, H. Jeffery, G. Atton, C. Karapouliou, G. Brice, K. Gordon, J.W. Wiseman, M. Wedin, S.G. Rockson, S. Jeffery, P.S. Mortimer, M.P. Snyder, S. Berland, S. Mansour, T. Makinen, and P. Ostergaard. (2016). EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis. J Clin Invest 126: 3080-3088. 27400125
Martinez, B.A., P. Reis Rodrigues, R.M. Nuñez Medina, P. Mondal, N.J. Harrison, M.A. Lone, A. Webster, A.U. Gurkar, B. Grill, and M.S. Gill. (2020). An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in. Elife 9:. 32096469
Matthias, L.J., P.T. Yam, X.M. Jiang, N. Vandegraaff, P. Li, P. Poumbourios, N. Donoghue, and P.J. Hogg. (2002). Disulfide exchange in domain 2 of CD4 is required for entry of HIV-1. Nat Immunol 3: 727-732. 12089508
Mezzadra, R., C. Sun, L.T. Jae, R. Gomez-Eerland, E. de Vries, W. Wu, M.E.W. Logtenberg, M. Slagter, E.A. Rozeman, I. Hofland, A. Broeks, H.M. Horlings, L.F.A. Wessels, C.U. Blank, Y. Xiao, A.J.R. Heck, J. Borst, T.R. Brummelkamp, and T.N.M. Schumacher. (2017). Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature 549: 106-110. 28813410
Mizushima, T., H. Yagi, E. Takemoto, M. Shibata-Koyama, Y. Isoda, S. Iida, K. Masuda, M. Satoh, and K. Kato. (2011). Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans. Genes Cells 16: 1071-1080. 22023369
Moreau, F., N.S. Kirk, F. Zhang, V. Gelfanov, E.O. List, M. Chrudinová, H. Venugopal, M.C. Lawrence, V. Jimenez, F. Bosch, J.J. Kopchick, R.D. DiMarchi, E. Altindis, and C. Ronald Kahn. (2022). Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist. Nat Commun 13: 6700. 36335114
Mu, L., Y. Wang, Y. Hu, C. Shi, B.A. Alman, C. Zhang, and J. She. (2022). The Role of TMIGD1 as a Tumor Suppressor in Colorectal Cancer. Genet Test Mol Biomarkers 26: 174-183. 35481970
Mulukala, S.K.N., S.S. Irukuvajjula, K. Kumar, K. Garai, P. Venkatesu, R. Vadrevu, and A.K. Pasupulati. (2020). Structural features and oligomeric nature of human podocin domain. Biochem Biophys Rep 23: 100774. 32617419
Muramatsu, T. (2016). Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners. J Biochem 159: 481-490. 26684586
Niu, G.J., S. Wang, J.D. Xu, M.C. Yang, J.J. Sun, Z.H. He, X.F. Zhao, and J.X. Wang. (2019). The polymeric immunoglobulin receptor-like protein from Marsupenaeus japonicus is a receptor for white spot syndrome virus infection. PLoS Pathog 15: e1007558. 30726286
Nyalali, A.M.K., A.U. Leonard, Y. Xu, H. Li, J. Zhou, X. Zhang, T.K. Rugambwa, X. Shi, and F. Li. (2023). CD147: an integral and potential molecule to abrogate hallmarks of cancer. Front Oncol 13: 1238051. 38023152
Ovens, M.J., C. Manoharan, M.C. Wilson, C.M. Murray, and A.P. Halestrap. (2010). The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein. Biochem. J. 431: 217-225. 20695846
Park, E.S., S.M. Jeon, H. Weon, H.J. Cho, and D.H. Youn. (2017). Activated leukocyte cell adhesion molecule is involved in excitatory synaptic transmission and plasticity in the rat spinal dorsal horn. Neurosci Lett 656: 9-14. 28720382
Park, H., F.G. Adsit, and J.C. Boyington. (2010). The 1.5 Å crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding. J. Biol. Chem. 285: 40762-40770. 20943659
Pu, X., L. Li, Z. Chen, A. Gong, J. Lei, L. Zhang, and H.I. Tsai. (2023). PERK/ATF3-Reduced ER Stress on high potassium environment in the suppression of tumor ferroptosis. J Cancer 14: 1336-1349. 37283787
Ramirez, R., A. Martin-Malo, and P. Aljama. (2007). Inflammation and hemodiafiltration. Contrib Nephrol 158: 210-215. 17684360
Raphael, I., R.R. Joern, and T.G. Forsthuber. (2020). Memory CD4 T Cells in Immunity and Autoimmune Diseases. Cells 9:. 32106536
Rathjen, F.G. (2020). The CAR group of Ig cell adhesion proteins-Regulators of gap junctions? Bioessays 42: e2000031. 33174233
Runkle, K.B., A. Kharbanda, E. Stypulkowski, X.J. Cao, W. Wang, B.A. Garcia, and E.S. Witze. (2016). Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling. Mol. Cell 62: 385-396. 27153536
Rupar, K., M.S. Isidor, L. Argemi-Muntadas, M. Agueda-Oyarzabal, K. Plucińska, E.L. Brown, M. Mattanovich, S. Bossi, M. Tozzi, D. Tandio, P.S.S. Petersen, T.I. Henriksen, K. Trošt, J.B. Hansen, Z. Gerhart-Hines, S. Nielsen, T. Moritz, and B. Emanuelli. (2023). Full activation of thermogenesis in brown adipocytes requires Basigin action. FEBS J. 290: 2673-2691. 36595342
Schäfer, M.K., Y.C. Nam, A. Moumen, L. Keglowich, E. Bouché, M. Küffner, H.H. Bock, F.G. Rathjen, C. Raoul, and M. Frotscher. (2010). L1 syndrome mutations impair neuronal L1 function at different levels by divergent mechanisms. Neurobiol Dis 40: 222-237. 20621658
Sharma, D., M.M. Balamurali, K. Chakraborty, S. Kumaran, S. Jeganathan, U. Rashid, P. Ingallinella, and R. Varadarajan. (2005). Protein minimization of the gp120 binding region of human CD4. Biochemistry 44: 16192-16202. 16331979
Sippel, C.J., F.J. Suchy, M. Ananthanarayanan, and D.H. Perlmutter. (1993). The rat liver ecto-ATPase is also a canalicular bile acid transport protein. J. Biol. Chem. 268: 2083-2091. 8420979
Sippel, C.J., M.J. McCollum, and D.H. Perlmutter. (1994). Bile acid transport by the rat liver canalicular bile acid transport/ecto-ATPase protein is dependent on ATP but not on its own ecto-ATPase activity. J. Biol. Chem. 269: 2820-2826. 8300615
Slack, J.L., K. Schooley, T.P. Bonnert, J.L. Mitcham, E.E. Qwarnstrom, J.E. Sims, and S.K. Dower. (2000). Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways. J. Biol. Chem. 275: 4670-4678. 10671496
Smith, E.R., S.G. Holt, and T.D. Hewitson. (2017). FGF23 activates injury-primed renal fibroblasts via FGFR4-dependent signalling and enhancement of TGF-β autoinduction. Int J Biochem. Cell Biol. 92: 63-78. 28919046
Son, S.M., J. Yun, D.W. Kim, Y.S. Jung, S.B. Han, Y.H. Lee, H.S. Han, C.G. Woo, H.C. Lee, and O.J. Lee. (2023). MicroRNA 29a therapy for CEACAM6-expressing lung adenocarcinoma. BMC Cancer 23: 843. 37684602
Steinberg, F., S.D. Gerber, T. Rieckmann, and B. Trueb. (2010). Rapid fusion and syncytium formation of heterologous cells upon expression of the FGFRL1 receptor. J. Biol. Chem. 285: 37704-37715. 20851884
Stogmann, E., E. Reinthaler, S. Eltawil, M.A. El Etribi, M. Hemeda, N. El Nahhas, A.M. Gaber, A. Fouad, S. Edris, A. Benet-Pages, S.H. Eck, E. Pataraia, D. Mei, A. Brice, S. Lesage, R. Guerrini, F. Zimprich, T.M. Strom, and A. Zimprich. (2013). Autosomal recessive cortical myoclonic tremor and epilepsy: association with a mutation in the potassium channel associated gene CNTN2. Brain 136: 1155-1160. 23518707
Suchy, F.J., C.J. Sippel, and M. Ananthanarayanan. (1997). Bile acid transport across the hepatocyte canalicular membrane. FASEB J. 11: 199-205. 9068608
Suzuki, J., E. Imanishi, and S. Nagata. (2016). Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure. Proc. Natl. Acad. Sci. USA 113: 9509-9514. 27503893
Tan-Sindhunata, M.B., I.B. Mathijssen, M. Smit, F. Baas, J.I. de Vries, J.P. van der Voorn, I. Kluijt, M.A. Hagen, E.W. Blom, E. Sistermans, H. Meijers-Heijboer, Q. Waisfisz, M.M. Weiss, and A.J. Groffen. (2015). Identification of a Dutch founder mutation in MUSK causing fetal akinesia deformation sequence. Eur J Hum Genet 23: 1151-1157. 25537362
Thüring, E.M., C. Hartmann, Y.A. Schwietzer, and K. Ebnet. (2023). TMIGD1: Emerging functions of a tumor supressor and adhesion receptor. Oncogene 42: 1777-1785. 37087524
Tiku, V., C. Jain, Y. Raz, S. Nakamura, B. Heestand, W. Liu, M. Späth, H.E.D. Suchiman, R.U. Müller, P.E. Slagboom, L. Partridge, and A. Antebi. (2017). Small nucleoli are a cellular hallmark of longevity. Nat Commun 8: 16083. 28853436
Togni, M., J. Lindquist, A. Gerber, U. Kölsch, A. Hamm-Baarke, S. Kliche, and B. Schraven. (2004). The role of adaptor proteins in lymphocyte activation. Mol Immunol 41: 615-630. 15219999
van Buul, J.D., M.J. Allingham, T. Samson, J. Meller, E. Boulter, R. García-Mata, and K. Burridge. (2007). RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. J. Cell Biol. 178: 1279-1293. 17875742
Vanlandewijck, M., T. Lebouvier, M. Andaloussi Mäe, K. Nahar, S. Hornemann, D. Kenkel, S.I. Cunha, J. Lennartsson, A. Boss, C.H. Heldin, A. Keller, and C. Betsholtz. (2015). Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification. PLoS One 10: e0143407. 26599395
Vit, O., P. Talacko, Z. Musil, I. Hartmann, K. Pacak, and J. Petrak. (2023). Identification of potential molecular targets for the treatment of cluster 1 human pheochromocytoma and paraganglioma via comprehensive proteomic characterization. Clin Proteomics 20: 39. 37749499
Vogel, B.E., J.M. Muriel, C. Dong, and X. Xu. (2006). Hemicentins: what have we learned from worms? Cell Res 16: 872-878. 17031392
Wang, L., M. Astone, S.K. Alam, Z. Zhu, W. Pei, D.A. Frank, S.M. Burgess, and L.H. Hoeppner. (2020). Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability. bioRxiv. 33140053
Wang, X., J. Zhang, B. Hu, and F. Qian. (2022). High Expression of CSF-1R Predicts Poor Prognosis and CSF-1R Tumor-Associated Macrophages Inhibit Anti-Tumor Immunity in Colon Adenocarcinoma. Front Oncol 12: 850767. 35444953
Wei, R., A. Sugiyama, Y. Sato, M. Nozumi, H. Nishino, M. Takahashi, T. Saito, K. Ando, M. Fukuda, M. Tomomura, M. Igarashi, and S.I. Hisanaga. (2020). Isoform-dependent subcellular localization of LMTK1A and LMTK1B and their roles in axon outgrowth and spine formation. J Biochem 168: 23-32. 32044995
Wei, S., S. Nandi, V. Chitu, Y.G. Yeung, W. Yu, M. Huang, L.T. Williams, H. Lin, and E.R. Stanley. (2010). Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. J Leukoc Biol 88: 495-505. 20504948
Wilson, M.C., D. Meredith, J.E. Fox, C. Manoharan, A.J. Davies, and A.P. Halestrap. (2005). Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J. Biol. Chem. 280: 27213-27221. 15917240
Wong, B.S., E.L. Dunnington, R. Wu, J.I. Kim, K. Hu, T.H. Ro, and D. Fu. (2024). Facilitated Transport of EGFR Inhibitors Plays an Important Role in Their Cellular Uptake. Anal Chem 96: 1547-1555. 38214696
Xie, S., C. Xu, C. Wu, Y. Lou, J. Duan, R. Sang, Z. Lou, J. Hou, W. Ge, Y. Xi, and X. Yang. (2023). Co-dependent regulation of p-BRAF and potassium channel KCNMA1 levels drives glioma progression. Cell Mol Life Sci 80: 61. 36763212
Xu, B., M. Zhang, B. Zhang, W. Chi, X. Ma, W. Zhang, M. Dong, L. Sheng, Y. Zhang, W. Jiao, Y. Shan, W. Chang, P. Wang, S. Wen, D. Pei, L. Chen, X. Zhang, H. Yan, and S. Ye. (2022). Embigin facilitates monocarboxylate transporter 1 localization to the plasma membrane and transition to a decoupling state. Cell Rep 40: 111343. 36103816
Xue, J., V. Rai, D. Singer, S. Chabierski, J. Xie, S. Reverdatto, D.S. Burz, A.M. Schmidt, R. Hoffmann, and A. Shekhtman. (2011). Advanced glycation end product recognition by the receptor for AGEs. Structure 19: 722-732. 21565706
Yeo, G.S., C.C. Connie Hung, J. Rochford, J. Keogh, J. Gray, S. Sivaramakrishnan, S. O'Rahilly, and I.S. Farooqi. (2004). A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Nat Neurosci 7: 1187-1189. 15494731
You, K., L. Wang, C.H. Chou, K. Liu, T. Nakata, A. Jaiswal, J. Yao, A. Lefkovith, A. Omar, J.G. Perrigoue, J.E. Towne, A. Regev, D.B. Graham, and R.J. Xavier. (2021). QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis. Science 371:. 33384352
Yu, X., W. Li, H. Liu, X. Wang, C. Coarfa, C. Cheng, X. Yu, Z. Zeng, Y. Cao, K.H. Young, and Y. Li. (2023). PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination. J Clin Invest 133:. 36719382
Yuguchi, T., B.N. Kanoi, H. Nagaoka, T. Miura, D. Ito, H. Takeda, T. Tsuboi, E. Takashima, and H. Otsuki. (2021). Erythrocyte Binding Like Protein Interacts With Basigin, an Erythrocyte Surface Protein. Front Cell Infect Microbiol 11: 656620. 33937099
Zhang, H., X. Tian, X. Lu, D. Xu, Y. Guo, Z. Dong, Y. Li, Y. Ma, C. Chen, Y. Yang, M. Yang, Y. Yang, F. Liu, R. Zhou, M. He, F. Xiao, and X. Wang. (2019). TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation. J Clin Invest 129: 3864-3876. 31424425
Zhang, L. and L. Xu. (2023). Fgf2 and Ptpn11 play a role in cerebral injury caused by sevoflurane anesthesia. Medicine (Baltimore) 102: e36108. 37960778
Zhen, A., S.R. Krutzik, B.R. Levin, S. Kasparian, J.A. Zack, and S.G. Kitchen. (2014). CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection. J. Virol. 88: 9934-9946. 24942581
Zhou, L., L. Zhu, X. Wu, S. Hu, S. Zhang, M. Ning, J. Yu, and M. Chen. (2023). Decreased TMIGD1 aggravates colitis and intestinal barrier dysfunction via the BANF1-NF-κB pathway in Crohn''s disease. BMC Med 21: 287. 37542259