8.A.137.1.1
Clathrin heavy chain 1 of 1675 aas, CLTC CLH17, CLTCL2 + clathrin light chain A of 248 aas, CCLTA. Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. It acts as a component of the TACC3/ch-TOG/clathrin complex, proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as an inter-microtubule bridge (Royle et al. 2005, Booth et al. 2011). The clathrin interactor 1 protein, CLTCL1, binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and may have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes It also stimulates clathrin assembly (Kalthoff et al. 2002; Mills et al. 2003).