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View Proteins belonging to: The Clathrin (Clathrin) Family

8.A.137.  The Clathrin (Clathrin) Family 

Clathrin impacts Wnt/beta-catenin signaling by controlling exocytosis of transmembrane proteins including cadherins and Wnt co-receptors that together control the membrane-bound and soluble pools of beta-catenin. Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. It acts as a component of the TACC3/ch-TOG/clathrin complex, proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as an inter-microtubule bridge (Royle et al. 2005, Royle and Lagnado 2006, Booth et al. 2011). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (Cheeseman et al. 2013). It also plays a role in early autophagosome formation (Ravikumar et al. 2010).

View Proteins belonging to: The Clathrin (Clathrin) Family

References associated with 8.A.137 family:

Booth, D.G., F.E. Hood, I.A. Prior, and S.J. Royle. (2011). A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. EMBO. J. 30: 906-919. 21297582
Cheeseman, L.P., E.F. Harry, A.D. McAinsh, I.A. Prior, and S.J. Royle. (2013). Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension. J Cell Sci 126: 2102-2113. 23532825
Kalthoff, C., S. Groos, R. Kohl, S. Mahrhold, and E.J. Ungewickell. (2002). Clint: a novel clathrin-binding ENTH-domain protein at the Golgi. Mol. Biol. Cell 13: 4060-4073. 12429846
Mills, I.G., G.J. Praefcke, Y. Vallis, B.J. Peter, L.E. Olesen, J.L. Gallop, P.J. Butler, P.R. Evans, and H.T. McMahon. (2003). EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking. J. Cell Biol. 160: 213-222. 12538641
Munthe, E., C. Raiborg, H. Stenmark, and E.M. Wenzel. (2020). Clathrin regulates Wnt/β-catenin signaling by affecting Golgi to plasma membrane transport of transmembrane proteins. J Cell Sci. [Epub: Ahead of Print] 32546530
Ravikumar, B., K. Moreau, L. Jahreiss, C. Puri, and D.C. Rubinsztein. (2010). Plasma membrane contributes to the formation of pre-autophagosomal structures. Nat. Cell Biol. 12: 747-757. 20639872
Royle, S.J. and L. Lagnado. (2006). Trimerisation is important for the function of clathrin at the mitotic spindle. J Cell Sci 119: 4071-4078. 16968737
Royle, S.J., N.A. Bright, and L. Lagnado. (2005). Clathrin is required for the function of the mitotic spindle. Nature 434: 1152-1157. 15858577