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|---|---|
| Accession Number: | P38919 |
| Protein Name: | Eukaryotic initiation factor 4A-III aka Eif4A3 |
| Length: | 411 |
| Molecular Weight: | 46871.00 |
| Species: | Homo sapiens (Human) [9606] |
| Location1 / Topology2 / Orientation3: | Nucleus1 |
| Substrate | messenger RNA |
Cross database links:
| RefSeq: | NP_055555.1 |
|---|---|
| Entrez Gene ID: | 9775 |
| Pfam: | PF00270 PF00271 |
| OMIM: |
608546 gene |
| KEGG: | hsa:9775 |
Gene Ontology
GO:0005737
C:cytoplasm
GO:0016607
C:nuclear speck
GO:0005681
C:spliceosomal complex
GO:0005524
F:ATP binding
GO:0004004
F:ATP-dependent RNA helicase activity
GO:0008143
F:poly(A) RNA binding
GO:0005515
F:protein binding
GO:0006397
P:mRNA processing
GO:0051028
P:mRNA transport
GO:0017148
P:negative regulation of translation
GO:0000184
P:nuclear-transcribed mRNA catabolic process,...
GO:0008380
P:RNA splicing
GO:0006364
P:rRNA processing
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References (26)[1] “Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.” Nagase T.et.al. 7788527 [2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [3] “DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.” Zody M.C.et.al. 16625196 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A.” Holzmann K.et.al. 10623621 [6] “Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.” Jurica M.S.et.al. 11991638 [7] “eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay.” Shibuya T.et.al. 15034551 [8] “eIF4A3 is a novel component of the exon junction complex.” Chan C.C.et.al. 14730019 [9] “Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia.” Simmons H.M.et.al. 15715967 [10] “Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements.” Gehring N.H.et.al. 16209946 [11] “The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.” Ballut L.et.al. 16170325 [12] “Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.” Tange T.O.et.al. 16314458 [13] “Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay.” Shibuya T.et.al. 16495234 [14] “MLN51 stimulates the RNA-helicase activity of eIF4AIII.” Noble C.G.et.al. 17375189 [15] “Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.” Wang B.et.al. 19007248 [16] “SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs.” Ma X.M.et.al. 18423201 [17] “Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.” Cantin G.T.et.al. 18220336 [18] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.” Daub H.et.al. 18691976 [19] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 [20] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.” Gauci S.et.al. 19413330 [21] “Exon junction complex enhances translation of spliced mRNAs at multiple steps.” Lee H.C.et.al. 19409878 [22] “Large-scale proteomics analysis of the human kinome.” Oppermann F.S.et.al. 19369195 | |
| Structure: | |
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MATTATMATS GSARKRLLKE EDMTKVEFET SEEVDVTPTF DTMGLREDLL RGIYAYGFEK 61: PSAIQQRAIK QIIKGRDVIA QSQSGTGKTA TFSISVLQCL DIQVRETQAL ILAPTRELAV 121: QIQKGLLALG DYMNVQCHAC IGGTNVGEDI RKLDYGQHVV AGTPGRVFDM IRRRSLRTRA 181: IKMLVLDEAD EMLNKGFKEQ IYDVYRYLPP ATQVVLISAT LPHEILEMTN KFMTDPIRIL 241: VKRDELTLEG IKQFFVAVER EEWKFDTLCD LYDTLTITQA VIFCNTKRKV DWLTEKMREA 301: NFTVSSMHGD MPQKERESIM KEFRSGASRV LISTDVWARG LDVPQVSLII NYDLPNNREL 361: YIHRIGRSGR YGRKGVAINF VKNDDIRILR DIEQYYSTQI DEMPMNVADL I