8.A.137.1.1
Clathrin heavy chain 1 of 1675 aas, CLTC CLH17, CLTCL2 + clathrin light chain A of 248 aas, CCLTA. Clathrin is the major protein of the polyhedral
coat of coated pits and vesicles. It acts as a component of the
TACC3/ch-TOG/clathrin complex, proposed to contribute to stabilization of
kinetochore fibers of the mitotic spindle by acting as an
inter-microtubule bridge (Royle et al. 2005, Booth et al. 2011). The clathrin interactor 1 protein, CLTCL1, binds to membranes enriched in
phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and may have a role
in transport via clathrin-coated vesicles from the trans-Golgi network
to endosomes It also stimulates clathrin assembly (Kalthoff et al. 2002; Mills et al. 2003).
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| Accession Number: | Q14677 |
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| Protein Name: | Clathrin interactor 1 |
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| Length: | 625 |
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| Molecular Weight: | 68259.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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1: MLNMWKVREL VDKATNVVMN YSEIESKVRE ATNDDPWGPS GQLMGEIAKA TFMYEQFPEL
61: MNMLWSRMLK DNKKNWRRVY KSLLLLAYLI RNGSERVVTS AREHIYDLRS LENYHFVDEH
121: GKDQGINIRQ KVKELVEFAQ DDDRLREERK KAKKNKDKYV GVSSDSVGGF RYSERYDPEP
181: KSKWDEEWDK NKSAFPFSDK LGELSDKIGS TIDDTISKFR RKDREDSPER CSDSDEEKKA
241: RRGRSPKGEF KDEEETVTTK HIHITQATET TTTRHKRTAN PSKTIDLGAA AHYTGDKASP
301: DQNASTHTPQ SSVKTSVPSS KSSGDLVDLF DGTSQSTGGS ADLFGGFADF GSAAASGSFP
361: SQVTATSGNG DFGDWSAFNQ APSGPVASSG EFFGSASQPA VELVSGSQSA LGPPPAASNS
421: SDLFDLMGSS QATMTSSQSM NFSMMSTNTV GLGLPMSRSQ NTDMVQKSVS KTLPSTWSDP
481: SVNISLDNLL PGMQPSKPQQ PSLNTMIQQQ NMQQPMNVMT QSFGAVNLSS PSNMLPVRPQ
541: TNALIGGPMP MSMPNVMTGT MGMAPLGNTP MMNQSMMGMN MNIGMSAAGM GLTGTMGMGM
601: PNIAMTSGTV QPKQDAFANF ANFSK