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3.A.18.1.1 The nuclear mRNA Export Complex (mRNA-E also called TREX) (including the exon junction complex) [TAP+p15 interact as a complex with the nuclear pore to facilitate mRNA transport to the cytoplasm] (Nojimma et al. 2007; Cheng et al., 2006)
Accession Number:	Q53GS7
Protein Name:	Nucleoporin GLE1
Length:	698
Molecular Weight:	79836.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	1
Location¹ / Topology² / Orientation³:	Cytoplasm¹
Substrate	messenger RNA

Structure:
Entrez Gene ID:	2733
Pfam:	PF07817
KEGG:	hsa:2733
Gene Ontology GO:0005737 C:cytoplasm GO:0005643 C:nuclear pore GO:0016973 P:poly(A)+ mRNA export from nucleus GO:0015031 P:protein transport
References (9) [1] “The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export.” Watkins J.L.et.al. 9618489 [2] “DNA sequence and analysis of human chromosome 9.” Humphray S.J.et.al. 15164053 [3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [4] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [5] “An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export.” Kendirgi F.et.al. 12668658 [6] “The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155.” Rayala H.J.et.al. 14645504 [7] “Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA.” Kendirgi F.et.al. 16000379 [8] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.” Mayya V.et.al. 19690332 [9] “Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease.” Nousiainen H.O.et.al. 18204449
6B4F 6B4I 6B4J

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

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FASTA formatted sequence

1:	MPSEGRCWET LKALRSSDKG RLCYYRDWLL RREDVLEECM SLPKLSSYSG WVVEHVLPHM 
61:	QENQPLSETS PSSTSASALD QPSFVPKSPD ASSAFSPASP ATPNGTKGKD ESQHTESMVL 
121:	QSSRGIKVEG CVRMYELVHR MKGTEGLRLW QEEQERKVQA LSEMASEQLK RFDEWKELKQ 
181:	HKEFQDLREV MEKSSREALG HQEKLKAEHR HRAKILNLKL REAEQQRVKQ AEQERLRKEE 
241:	GQIRLRALYA LQEEMLQLSQ QLDASEQHKA LLKVDLAAFQ TRGNQLCSLI SGIIRASSES 
301:	SYPTAESQAE AERALREMRD LLMNLGQEIT RACEDKRRQD EEEAQVKLQE AQMQQGPEAH 
361:	KEPPAPSQGP GGKQNEDLQV KVQDITMQWY QQLQDASMQC VLTFEGLTNS KDSQAKKIKM 
421:	DLQKAATIPV SQISTIAGSK LKEIFDKIHS LLSGKPVQSG GRSVSVTLNP QGLDFVQYKL 
481:	AEKFVKQGEE EVASHHEAAF PIAVVASGIW ELHPRVGDLI LAHLHKKCPY SVPFYPTFKE 
541:	GMALEDYQRM LGYQVKDSKV EQQDNFLKRM SGMIRLYAAI IQLRWPYGNR QEIHPHGLNH 
601:	GWRWLAQILN MEPLSDVTAT LLFDFLEVCG NALMKQYQVQ FWKMLILIKE DYFPRIEAIT 
661:	SSGQMGSFIR LKQFLEKCLQ HKDIPVPKGF LTSSFWRS

3.A.18.1.1
The nuclear mRNA Export Complex (mRNA-E also called TREX) (including the exon junction complex) [TAP+p15 interact as a complex with the nuclear pore to facilitate mRNA transport to the cytoplasm] (Nojimma et al. 2007; Cheng et al., 2006)

Cross database links:

Gene Ontology

References (9)

External Searches:

Analyze:

3.A.18.1.1The nuclear mRNA Export Complex (mRNA-E also called TREX) (including the exon junction complex) [TAP+p15 interact as a complex with the nuclear pore to facilitate mRNA transport to the cytoplasm] (Nojimma et al. 2007; Cheng et al., 2006)

Cross database links:

Gene Ontology

References (9)

External Searches:

Analyze:

3.A.18.1.1
The nuclear mRNA Export Complex (mRNA-E also called TREX) (including the exon junction complex) [TAP+p15 interact as a complex with the nuclear pore to facilitate mRNA transport to the cytoplasm] (Nojimma et al. 2007; Cheng et al., 2006)