1.X.1.1.1
The Intraflagellar transporter (IFT) multiprotein complex. WD repeat-containing protein 35 of 1181 aas and possibly as many as 7 or 8 TMSs. It is a component of the IFT complex A (IFT-A), a complex required for
retrograde ciliary transport and entry into cilia of G protein-coupled
receptors (GPCRs). It is thus involved in ciliogenesis and ciliary protein
trafficking (Takahara et al. 2018) (see the family description). Many other proteins play a role as constituents of the IFT complex, and some of these (but not all of them) are listed under this TC# (Lechtreck 2022).
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| Accession Number: | Q8WVS4 |
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| Protein Name: | Cytoplasmic dynein 2 intermediate chain 1 |
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| Length: | 1066 |
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| Molecular Weight: | 122571.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell projection1 |
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| Substrate |
protein |
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1: MEPGKRRTKD DTWKADDLRK HLWAIQSGGS KEERKHREKK LRKESEMDLP EHKEPRCRDP
61: DQDARSRDRV AEVHTAKESP RGERDRDRQR ERRRDAKDRE KEKLKEKHRE AEKSHSRGKD
121: REKEKDRRAR KEELRQTVAH HNLLGQETRD RQLLERAERK GRSVSKVRSE EKDEDSERGD
181: EDRERRYRER KLQYGDSKDN PLKYWLYKEE GERRHRKPRE PDRDNKHREK SSTREKREKY
241: SKEKSNSFSD KGEERHKEKR HKEGFHFDDE RHQSNVDRKE KSAKDEPRKR ESQNGEHRNR
301: GASSKRDGTS SQHAENLVRN HGKDKDSRRK HGHEEGSSVW WKLDQRPGGE ETVEIEKEET
361: DLENARADAY TASCEDDFED YEDDFEVCDG DDDESSNEPE SREKLEELPL AQKKEIQEIQ
421: RAINAENERI GELSLKLFQK RGRTEFEKEP RTDTNSSPSR ASVCGIFVDF ASASHRQKSR
481: TQALKQKMRS TKLLRLIDLD FSFTFSLLDL PPVNEYDMYI RNFGKKNTKQ AYVQCNEDNV
541: ERDIQTEEIE TREVWTQHPG ESTVVSGGSE QRDTSDAVVM PKIDTPRLCS FLRAACQVMA
601: VLLEEDRLAA EPSWNLRAQD RALYFSDSSS QLNTSLPFLQ NRKVSSLHTS RVQRQMVVSV
661: HDLPEKSFVP LLDSKYVLCV WDIWQPSGPQ KVLICESQVT CCCLSPLKAF LLFAGTAHGS
721: VVVWDLREDS RLHYSVTLSD GFWTFRTATF STDGILTSVN HRSPLQAVEP ISTSVHKKQS
781: FVLSPFSTQE EMSGLSFHIA SLDESGVLNV WVVVELPKAD IAGSISDLGL MPGGRVKLVH
841: SALIQLGDSL SHKGNEFWGT TQTLNVKFLP SDPNHFIIGT DMGLISHGTR QDLRVAPKLF
901: KPQQHGIRPV KVNVIDFSPF GEPIFLAGCS DGSIRLHQLS SAFPLLQWDS STDSHAVTGL
961: QWSPTRPAVF LVQDDTSNIY IWDLLQSDLG PVAKQQVSPN RLVAMAAVGE PEKAGGSFLA
1021: LVLARASGSI DIQHLKRRWA APEVDECNRL RLLLQEALWP EGKLHK