1.X.1. The Intraflagellar Transporter-A Complex (Ift-A) Family
The Ift-A complex appears to be a multicomponent complex that functions to transport flagellar/ciliary membrane proteins under the eukaryotic ciliary membrane. As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking (Mill et al. 2011, Duran et al. 2017, Takahara et al. 2018). Not all of the ItfA complex have been identified. Here, we list only a few of them.
References associated with 1.X.1 family:
Duran, I., S.P. Taylor, W. Zhang, J. Martin, F. Qureshi, S.M. Jacques, R. Wallerstein, R.S. Lachman, D.A. Nickerson, M. Bamshad, D.H. Cohn, and D. Krakow. (2017). Mutations in IFT-A satellite core component genes and produce short rib polydactyly syndrome with distinctive campomelia. Cilia 6: 7. 28400947
Lechtreck, K. (2022). Cargo adapters expand the transport range of intraflagellar transport. J Cell Sci 135:. 36533425
Mill, P., P.J. Lockhart, E. Fitzpatrick, H.S. Mountford, E.A. Hall, M.A. Reijns, M. Keighren, M. Bahlo, C.J. Bromhead, P. Budd, S. Aftimos, M.B. Delatycki, R. Savarirayan, I.J. Jackson, and D.J. Amor. (2011). Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis. Am J Hum Genet 88: 508-515. 21473986
Reddy Palicharla, V. and S. Mukhopadhyay. (2024). Molecular and structural perspectives on protein trafficking to the primary cilium membrane. Biochem Soc Trans 52: 1473-1487. 38864436
Takahara, M., Y. Katoh, K. Nakamura, T. Hirano, M. Sugawa, Y. Tsurumi, and K. Nakayama. (2018). Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis. Hum Mol Genet 27: 516-528. 29220510
Werner, S., P. Okenve-Ramos, P. Hehlert, S. Zitouni, P. Priya, S. Mendonça, A. Sporbert, C. Spalthoff, M.C. Göpfert, S.C. Jana, and M. Bettencourt-Dias. (2024). IFT88 maintains sensory function by localising signalling proteins along cilia. Life Sci Alliance 7:. 38373798