| |
|---|---|
| Accession Number: | Q9H307 |
| Protein Name: | Pinin |
| Length: | 717 |
| Molecular Weight: | 81614.00 |
| Species: | Homo sapiens (Human) [9606] |
| Location1 / Topology2 / Orientation3: | Nucleus speckle1 |
| Substrate | messenger RNA |
Cross database links:
| RefSeq: | NP_002678.2 |
|---|---|
| Entrez Gene ID: | 5411 |
| Pfam: | PF04696 PF04697 |
| OMIM: |
603154 gene |
| KEGG: | hsa:5411 |
Gene Ontology
GO:0030057
C:desmosome
GO:0005882
C:intermediate filament
GO:0016607
C:nuclear speck
GO:0005681
C:spliceosomal complex
GO:0003677
F:DNA binding
GO:0005515
F:protein binding
GO:0005198
F:structural molecule activity
GO:0007155
P:cell adhesion
GO:0006397
P:mRNA processing
GO:0045449
P:regulation of transcription
GO:0008380
P:RNA splicing
GO:0006350
P:transcription
| |
References (30)[1] “Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex.” Ouyang P.et.al. 8922384 [2] “memA/DRS, a putative mediator of multiprotein complexes, is overexpressed in the metastasizing human melanoma cell lines BLM and MV3.” Degen W.G.J.et.al. 10095061 [3] “Characterization of the gene encoding pinin/DRS/memA and evidence for its potential tumor suppressor function.” Shi Y.et.al. 10645008 [4] “Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.” Hu R.-M.et.al. 10931946 [5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “Evidence that 'pinin', reportedly a differentiation-specific desmosomal protein, is actually a widespread nuclear protein.” Brandner J.et.al. 9447706 [8] “Antibodies differentiate desmosome-form and nucleus-form pinin: evidence that pinin is a moonlighting protein with dual location at the desmosome and within the nucleus.” Ouyang P.et.al. 10486276 [9] “Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus.” Shi J.et.al. 10809736 [10] “Modulation of alternative pre-mRNA splicing in vivo by pinin.” Wang P.et.al. 12051732 [11] “Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.” Jurica M.S.et.al. 11991638 [12] “Molecular characterization of a novel nucleolar protein, pNO40.” Chang W.-L.et.al. 12893261 [13] “Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells.” Zimowska G.et.al. 14578391 [14] “Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1.” Li C.et.al. 14517304 [15] “Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles.” Lin C.L.et.al. 15358154 [16] “Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo.” Sakashita E.et.al. 14729963 [17] “Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene.” Alpatov R.et.al. 15542832 [18] “Reduction of Pnn by RNAi induces loss of cell-cell adhesion between human corneal epithelial cells.” Joo J.-H.et.al. 15735603 [19] “Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.” Tange T.O.et.al. 16314458 [20] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.” Olsen J.V.et.al. 17081983 [21] “A probability-based approach for high-throughput protein phosphorylation analysis and site localization.” Beausoleil S.A.et.al. 16964243 [22] “Phosphoproteome analysis of the human mitotic spindle.” Nousiainen M.et.al. 16565220 [23] “Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.” Molina H.et.al. 17287340 [24] “ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.” Matsuoka S.et.al. 17525332 [25] “Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.” Wang B.et.al. 19007248 [26] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.” Daub H.et.al. 18691976 | |
External Searches:
|
Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
|
|||
1: MAVAVRTLQE QLEKAKESLK NVDENIRKLT GRDPNDVRPI QARLLALSGP GGGRGRGSLL 61: LRRGFSDSGG GPPAKQRDLE GAVSRLGGER RTRRESRQES DPEDDDVKKP ALQSSVVATS 121: KERTRRDLIQ DQNMDEKGKQ RNRRIFGLLM GTLQKFKQES TVATERQKRR QEIEQKLEVQ 181: AEEERKQVEN ERRELFEERR AKQTELRLLE QKVELAQLQE EWNEHNAKII KYIRTKTKPH 241: LFYIPGRMCP ATQKLIEESQ RKMNALFEGR RIEFAEQINK MEARPRRQSM KEKEHQVVRN 301: EEQKAEQEEG KVAQREEELE ETGNQHNDVE IEEAGEEEEK EIAIVHSDAE KEQEEEEQKQ 361: EMEVKMEEET EVRESEKQQD SQPEEVMDVL EMVENVKHVI ADQEVMETNR VESVEPSENE 421: ASKELEPEME FEIEPDKECK SLSPGKENVS ALDMEKESEE KEEKESEPQP EPVAQPQPQS 481: QPQLQLQSQS QPVLQSQPPS QPEDLSLAVL QPTPQVTQEQ GHLLPERKDF PVESVKLTEV 541: PVEPVLTVHP ESKSKTKTRS RSRGRARNKT SKSRSRSSSS SSSSSSSTSS SSGSSSSSGS 601: SSSRSSSSSS SSTSGSSSRD SSSSTSSSSE SRSRSRGRGH NRDRKHRRSV DRKRRDTSGL 661: ERSHKSSKGG SSRDTKGSKD KNSRSDRKRS ISESSRSGKR SSRSERDRKS DRKDKRR