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|---|---|
| Accession Number: | Q9NPI6 |
| Protein Name: | mRNA-decapping enzyme 1A aka hUpf3 aka DCP1A |
| Length: | 582 |
| Molecular Weight: | 63309.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 1 |
| Location1 / Topology2 / Orientation3: | Cytoplasm1 |
| Substrate | messenger RNA |
Cross database links:
| RefSeq: | NP_060873.4 |
|---|---|
| Entrez Gene ID: | 55802 |
| Pfam: | PF06058 |
| OMIM: |
607010 gene |
| KEGG: | hsa:55802 |
Gene Ontology
GO:0000932
C:cytoplasmic mRNA processing body
GO:0005634
C:nucleus
GO:0016787
F:hydrolase activity
GO:0005515
F:protein binding
GO:0000184
P:nuclear-transcribed mRNA catabolic process,...
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References (16)[1] “Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.” Lykke-Andersen J.et.al. 12417715 [2] “SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling.” Bai R.-Y.et.al. 11836524 [3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [4] “The DNA sequence, annotation and analysis of human chromosome 3.” Muzny D.M.et.al. 16641997 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [6] “The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.” Ingelfinger D.et.al. 12515382 [7] “Large-scale characterization of HeLa cell nuclear phosphoproteins.” Beausoleil S.A.et.al. 15302935 [8] “Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.” Fenger-Groen M.et.al. 16364915 [9] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.” Olsen J.V.et.al. 17081983 [10] “Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.” Imami K.et.al. 18187866 [11] “Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.” Cantin G.T.et.al. 18220336 [12] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.” Daub H.et.al. 18691976 [13] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 [14] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.” Gauci S.et.al. 19413330 [15] “Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex.” Cho H.et.al. 19150429 [16] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.” Mayya V.et.al. 19690332
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| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MEALSRAGQE MSLAALKQHD PYITSIADLT GQVALYTFCP KANQWEKTDI EGTLFVYRRS 61: ASPYHGFTIV NRLNMHNLVE PVNKDLEFQL HEPFLLYRNA SLSIYSIWFY DKNDCHRIAK 121: LMADVVEEET RRSQQAARDK QSPSQANGCS DHRPIDILEM LSRAKDEYER NQMGDSNISS 181: PGLQPSTQLS NLGSTETLEE MPSGSQDKSA PSGHKHLTVE ELFGTSLPKE QPAVVGLDSE 241: EMERLPGDAS QKEPNSFLPF PFEQLGGAPQ SETLGVPSAA HHSVQPEITT PVLITPASIT 301: QSNEKHAPTY TIPLSPVLSP TLPAEAPTAQ VPPSLPRNST MMQAVKTTPR QRSPLLNQPV 361: PELSHASLIA NQSPFRAPLN VTNTAGTSLP SVDLLQKLRL TPQHDQIQTQ PLGKGAMVAS 421: FSPAAGQLAT PESFIEPPSK TAAARVAASA SLSNMVLAPL QSMQQNQDPE VFVQPKVLSS 481: AIQVAGAPLV TATTTAVSSV LLAPSVFQQT VTRSSDLERK ASSPSPLTIG TPESQRKPSI 541: ILSKSQLQDT LIHLIKNDSS FLSTLHEVYL QVLTKNKDNH NL