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3.A.20.1.3
Glycosomal membrane protein insertion apparatus.  Two proteins included in the system are PEX14 and PEX19 which target to the peroxisome in several other organisms, but in T. brucei, they target to the glycosome.  By contrast, PEX10 and PEX12 are involved in targetting to the peroxisome (Saveria et al. 2007). Altogether, PEX1, 2, 5, 6, 10, 11, 12, 14, 16, and 19 have been identified in T. brucei and are listed here. Inhibitors of PEX14 block protein import into glycosomes and kill Trypanosma parasites (Dawidowski et al. 2017). The glycosomal membrane-associated Leishmania donovani protein PEX14, which plays a crucial role in protein import from the cytosol to the glycosomal matrix, consists of three domains: an N-terminal domain where the signalling molecule binds, a transmembrane domain and an 84-residue coiled-coil domain (CC) that is responsible for oligomerization. CCs are versatile domains that participate in a variety of functions including supramolecular assembly, cellular signalling and transport (Shakya and Pratap 2020).

Accession Number:Q9U7C3
Protein Name:Peroxisome targeting signal 1 receptor PEX5
Length:655
Molecular Weight:72066.00
Species:Trypanosoma brucei [5691]
Substrate protein polypeptide chain

Cross database links:

Structure:
1HXI   3CVL   3CVN     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDCGAGFALG QQLAKDALHM QGGVRPGTTG NVEQDALMTG MMVPPTGPME DWAQHFAAHQ 
61:	HHHQQHQQMM MQRQHNDALM IQQQHRDMEE AFRASARAGA PQQANAGPLM MPPGPMMMAG 
121:	GMAPMMHAGG FMMGGMPQMM PCAPMGMNMG MAPVATMSPA TTNTVSGARE GATAVSSAAP 
181:	GVVDLGGDSA WAEKLHQAEW GQDYKDVEVH TVEGSTAQTV EEHAKTSKFY EFMDKIRKKE 
241:	LLVDEDSGEV VQGPGPDPDV EADTEYLARL AAMEGINVPP SVMDHMQGQD GVQRGTDEDM 
301:	EGMMGDDVYD PSADVEQWAQ EYAQMQAMQE RLQNNTDYPF EANNPYMYHE NPMEEGLSML 
361:	KLANLAEAAL AFEAVCQKEP EREEAWRSLG LTQAENEKDG LAIIALNHAR MLDPKDIAVH 
421:	AALAVSHTNE HNANAALASL RAWLLSQPQY EQLGSVNLQA DVDIDDLNVQ SEDFFFAAPN 
481:	EYRECRTLLH AALEMNPNDA QLHASLGVLY NLSNNYDSAA ANLRRAVELR PDDAQLWNKL 
541:	GATLANGNRP QEALDAYNRA LDINPGYVRV MYNMAVSYSN MSQYDLAAKQ LVRAIYMQVG 
601:	GTTPTGEASR EATRSMWDFF RMLLNVMNRP DLVELTYAQN VEPFAKEFGL QSMLL