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|---|---|
| Accession Number: | Q9UBU9 |
| Protein Name: | Nuclear RNA export factor 1 aka TAP aka NXF1 aka REF |
| Length: | 619 |
| Molecular Weight: | 70182.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 1 |
| Location1 / Topology2 / Orientation3: | Nucleus1 |
| Substrate | messenger RNA |
Cross database links:
| RefSeq: | NP_006353.2 |
|---|---|
| Entrez Gene ID: | 10482 |
| Pfam: | PF00560 PF02136 PF03943 |
| OMIM: |
602647 gene |
Gene Ontology
GO:0005737
C:cytoplasm
GO:0016607
C:nuclear speck
GO:0000166
F:nucleotide binding
GO:0005515
F:protein binding
GO:0044419
P:interspecies interaction between organisms
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References (24)[1] “TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus.” Braun I.C.et.al. 10202158 [2] “The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences.” Kang Y.et.al. 10323864 [3] “Identification of novel import and export signals of human TAP, the protein that binds to the constitutive transport element of the type D retrovirus mRNAs.” Bear J.et.al. 10454577 [4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [5] “Human chromosome 11 DNA sequence and analysis including novel gene identification.” Taylor T.D.et.al. 16554811 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation.” Yoon D.-W.et.al. 9175835 [8] “TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus.” Grueter P.et.al. 9660949 [9] “The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human.” Katahira J.et.al. 10228171 [10] “Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export.” Braun I.C.et.al. 11259411 [11] “The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.” Bachi A.et.al. 10668806 [12] “Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins.” Suyama M.et.al. 11256625 [13] “Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex.” Kataoka N.et.al. 11707413 [14] “Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex.” Kim V.N.et.al. 11546873 [15] “Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1.” Lykke-Andersen J.et.al. 11546874 [16] “eIF4A3 is a novel component of the exon junction complex.” Chan C.C.et.al. 14730019 [17] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.” Gauci S.et.al. 19413330 [18] “UIF, a new mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA.” Hautbergue G.M.et.al. 19836239 [19] “Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.” Katahira J.et.al. 19165146 [20] “Assembly and mobility of exon-exon junction complexes in living cells.” Schmidt U.et.al. 19324961 [21] “The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain.” Liker E.et.al. 11060011 [22] “Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor.” Fribourg S.et.al. 11583626 | |
| Structure: | |
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MADEGKSYSE HDDERVNFPQ RKKKGRGPFR WKYGEGNRRS GRGGSGIRSS RLEEDDGDVA 61: MSDAQDGPRV RYNPYTTRPN RRGDTWHDRD RIHVTVRRDR APPERGGAGT SQDGTSKNWF 121: KITIPYGRKY DKAWLLSMIQ SKCSVPFTPI EFHYENTRAQ FFVEDASTAS ALKAVNYKIL 181: DRENRRISII INSSAPPHTI LNELKPEQVE QLKLIMSKRY DGSQQALDLK GLRSDPDLVA 241: QNIDVVLNRR SCMAATLRII EENIPELLSL NLSNNRLYRL DDMSSIVQKA PNLKILNLSG 301: NELKSERELD KIKGLKLEEL WLDGNSLCDT FRDQSTYISA IRERFPKLLR LDGHELPPPI 361: AFDVEAPTTL PPCKGSYFGT ENLKSLVLHF LQQYYAIYDS GDRQGLLDAY HDGACCSLSI 421: PFIPQNPARS SLAEYFKDSR NVKKLKDPTL RFRLLKHTRL NVVAFLNELP KTQHDVNSFV 481: VDISAQTSTL LCFSVNGVFK EVDGKSRDSL RAFTRTFIAV PASNSGLCIV NDELFVRNAS 541: SEEIQRAFAM PAPTPSSSPV PTLSPEQQEM LQAFSTQSGM NLEWSQKCLQ DNNWDYTRSA 601: QAFTHLKAKG EIPEVAFMK