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1.A.131.1.4 Trp-like channel protein of 862 aas and 12 TMSs in a 1 + 1 + 2 + 4 + 4 TMS arrangement. Pkd2 mutations, related to autosomal dominant polycystic kidney disease in humans, localizes to the endoplasmic reticulum and regulates calcium signaling in fission yeast (Koyano et al. 2023).
Accession Number:	O94543
Protein Name:	Uncharacterized membrane protein C1322.03
Length:	862
Molecular Weight:	97438.00
Species:	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [284812]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Cytoplasm¹
Substrate

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MKPRPYSVFL FLHIVFYSLL SAVNGSPSLD YFETCSNFVP RAGIPTFSPY AVIKNFDEVN 
61:	RMYYIQVVGN LSGVITIVGG NGSHIHAASV YSETYALGKL VTSNTTKLCD VVMDPHSFEV 
121:	PIKCPWAAGS AAFMVKVPFK STLSDYSKYE LTTLTTRVIV VDGTPEKNVI TCMKFGLSTT 
181:	LYYFYPVISY LVVVSLAYVS FSIIYALFLN PWTGSLDPFK SIFNFNMDPD ALRLTSLGFF 
241:	DFVQYLQFAV STAQVSVMFP KFYINIMAAL SWGTALFRFP IFSEPAEYQF ADFADLSVAS 
301:	SSYADYLPKS YGMYSFLDSI GIGTACWLPF LIVMVIYLFA ALFVALLVIF LKWLMSRIFN 
361:	ETIAETRWDT WSFIAGSLIR LYFLTYFPTV AYMSFQFVAP PTGYEIIPVL WFIFFGIFIP 
421:	VYLYMNLAFV EPSSKLLEDQ TYLHLFGSIY NSFREERVMF WIFPIAVQFM RGITVGVIGS 
481:	SGSAQLAIFF ILEVANVVAY AYVRPHFPQT SMNTLNTFIS TMRLITVILM IPLDPRLKVL 
541:	GISRDLLAYA ILFIHIMVCI LFLLLSTQRF MEVSARLLGA KSESKGVPLD RPFGWARVFG 
601:	INELRRRRLK DPYSNGNTMM FDHSTYNSNE MSVPLTPVSV CSNSLKKDGE AAPPKLFVQT 
661:	NCIPPVTQAS SLVPSKNNTA SSSSLMLDSP VTPSSPYSTS QGYSFYRPPK PKSSVRKRDM 
721:	DQLRALQLDF LNNKPNLLRH DVNYAVREAD VYHPHVDTSI DSLSQISSQP FEMRPTAIPP 
781:	PPKNAFQRAW QIVQSTAKSI WHSDPPKESE KGFVVLRSRP RPNLQKPLPQ LHIEPSRDEQ 
841:	YSMERKKTDD SLAESAWSIP HP

1.A.131.1.4
Trp-like channel protein of 862 aas and 12 TMSs in a 1 + 1 + 2 + 4 + 4 TMS arrangement. Pkd2 mutations, related to autosomal dominant polycystic kidney disease in humans, localizes to the endoplasmic reticulum and regulates calcium signaling in fission yeast (Koyano et al. 2023).

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1.A.131.1.4Trp-like channel protein of 862 aas and 12 TMSs in a 1 + 1 + 2 + 4 + 4 TMS arrangement. Pkd2 mutations, related to autosomal dominant polycystic kidney disease in humans, localizes to the endoplasmic reticulum and regulates calcium signaling in fission yeast (Koyano et al. 2023).

Cross database links:

External Searches:

Analyze:

1.A.131.1.4
Trp-like channel protein of 862 aas and 12 TMSs in a 1 + 1 + 2 + 4 + 4 TMS arrangement. Pkd2 mutations, related to autosomal dominant polycystic kidney disease in humans, localizes to the endoplasmic reticulum and regulates calcium signaling in fission yeast (Koyano et al. 2023).