| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
1.A.131.1.1 | Flavin carrier protein 1 (Bypass of PAM1 protein 1) (FAD transporter 1) (Heme utilization factor 1) (TRP-like ion channel protein FLC1) | Eukaryota |
Fungi, Ascomycota | FLC1 of Saccharomyces cerevisiae |
|
1.A.131.1.2 | TRP-like ion channel PKD2 (Polycystic kidney disease-related ion channel 2). It regulates cytoplasmic calcium ion concentrations (Ma et al. 2011). The functions of Pkd2 include playing roles in cell wall synthesis, membrane protein trafficking and regulating cell separation during cytokinesis (Aydar and Palmer 2009; Morris et al. 2019). The protein has 710 aas and 9 TMSs in a 1 (N-terminus) + 1 (at residue 180) +3 (residues 320 - 420) + 4 (residues 470 - 580). | Eukaryota |
Fungi, Ascomycota | Pkd2 of Schizosaccharomyces pombe |
|
1.A.131.1.3 | Flavin carrier protein 2, Flc2p. May be responsible for the transport of FAD (and heme) into the endoplasmic reticulum lumen, where FAD may be required for oxidative protein folding involved in disulfide bridge formation (Protchenko et al. 2006). | Eukaryota |
Fungi, Ascomycota | Flc2 of Saccharomyces cerevisiae |
|
1.A.131.1.4 | Trp-like channel protein of 862 aas and 12 TMSs in a 1 + 1 + 2 + 4 + 4 TMS arrangement. Pkd2 mutations, related to autosomal dominant polycystic kidney disease in humans, localizes to the endoplasmic reticulum and regulates calcium signaling in fission yeast (Koyano et al. 2023). | Eukaryota |
Fungi, Ascomycota | TRP-like channel protein of Schizosaccharomyes pombe (O94543) |
|
1.A.131.1.5 | Inner membrane TRP Ca2+ channel, TrpR, of 1134 aas and ~9 TMSs. TrpR works as a Golgi membrane calcium ion channel that influences cell wall integration (Wang et al. 2021). It performs important roles in conidiation and in adapting to cell wall disruption reagents in a high temperature-induced defect-dependent manner, especially under calcium-limited culture conditions (Wang et al. 2021). | Eukaryota |
Fungi, Ascomycota | TrpR of Emericella nidulans (Aspergillus nidulans) |
|
1.A.131.1.6 | DUF907 domain-containing protein of 794 aas and 7 TMSs in the C-terminal half of the protein and possibly 1 or 2 additional TMSs in the N-terminal half. This protein shows extensive sequence similarity with other members of subfamily 1.A.4.9. It may be the TRP protein described by Guo et al. 2022. The VdASP F2 protein has been reported to regulate the formation of melanized microsclerotia by interacting with VdTRP (Guo et al. 2022). . | Eukaryota |
Fungi, Ascomycota | DUF907 protein of Verticillium dahliae |
|
1.A.131.1.7 | Integral membrane protein of 1180 aas and 10 TMSs in a 1 + 2 + 7 TMS arrangement. It may be the TRP protein examined by Guo et al. 2022. | Eukaryota |
Fungi, Ascomycota | IMP of Verticillium dahliae |
|
1.A.131.1.8 | TRP-domain-containing protein of 925 aas and 9 putative TMSs in a 2 + 3 + 4 TMS pattern, where the 3 TMS cluster may be a helix-p-loop- helix channel forming unit. This would be true of all family members. | Eukaryota |
Fungi, Ascomycota | TRP protein of Annulohypoxylon bovei var. microspora |
|
1.A.131.1.9 | Putative transient receptor potential ion channel of 781 aas and 9 TMSs in a possible 2 + 3 + 1 + 3 TMS arrangement. | Eukaryota |
Fungi, Ascomycota | Putative TRP channel of Phaeomoniella chlamydospora |