1.A.148.1.1
Pore-forming protein after proteolysis to yield peptides. Four such peptides have been released and shown to form pores in the parasitophorous vacuole of T. gonadii (Jastrab and Darwin 2015; Bitew et al. 2024) (see family description). This protein is GRA47 (gene ID TGGT1_254000 = EPR59035.1) and has two TMSs near the N-terminus (residues 50 and 170) separated by a semi hydrophobic sequence that could resemble a P-loop as in members of the VIC (voltage-gated ion channel) (TC# 1.A.1) protein members. The same characteristic is observed for other members of this family.
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| Accession Number: | PIL98022.1 |
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| Protein Name: | PIL98022.1 hypothetical protein TGCOUG_254000 [Toxoplasma gondii COUG] |
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| Length: | 477 |
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| Molecular Weight: | |
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| Species: | Toxoplasma gondii COUG [1074873] |
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| Substrate |
ion |
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1: MKVVSVHASH PSASGLRGLA SLPRSRAFCV VMARPASRPS RPSTASVGRR LSGSFLLVAL
61: ALACSPAPPS LSPPSRSPTS FLPNASFAAC MAPPPPNQIG DIKRVVLRLE TKDGKVYDLN
121: VGGLQAVAGG APQLGVTPGV GVSGSGAARP VDRSAQERRP SMWSRVSQHA ANTLVASVLF
181: LSIGEAYSWL KRHSQEKQKR LAREEVAREK AAIASRLREV EERLTVLEDV EEAAERGEGQ
241: LTGKQKADLS ILRSEREDLL AQQRRNALRD GQLNGFPVKK TSFASLLDGR SRSRVRRGSK
301: ESRRQNSGSQ SDEEDVEESD EDARALRADD RDGRSAPGAA KNFLDRRQIE RSGAKKGDAG
361: SEETQKALAG DSEEKASKKT GETKTAEAGD AGNAGNAGEV GRPRSQTRER KSQRKDAKER
421: SHASEDEDDF ALLRSGGSSG SEKMKYITQL LAEHPGMSPE EAIEMLNFMS NGKRGS