1.A.2.1.20
Irk2 of 453 aas and 2 TMSs and a P-loop between them. Small molecule potassium ion channel agonist/antagonist
screen reveals seizure suppression via glial Irk2 activation in a
Drosophila model of Dup15q syndrome (Geier et al. 2025).
|
| Accession Number: | Q9VCL9 |
|---|
| Protein Name: | GH11459p |
|---|
| Length: | 453 |
|---|
| Molecular Weight: | 51793.00 |
|---|
| Species: | Drosophila melanogaster (Fruit fly) [7227] |
|---|
| Number of TMSs: | 4 |
|---|
| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
potassium(1+) |
|---|
1: MRFNFSTHSA APTSTTIPTT TQANGGEQAT QPLKKAIEAD PDSLDSVISN PQSYPITIVP
61: NRPTSYYGLS QNGKPFPRQP SCRSRNFRPG SMRRVRRRAV FKNGDCNVVQ KHLQRRRVRF
121: LQDMYTTMVD WQWRWTLLAF ALSFILSWLF FALIWWLIIY THGDLEEPHL PENQEESGWA
181: PCVSAIDGFT SCFLFSIETQ HTIGYGVRTT SPECPEAIFM MCFQSIYGVM SSAFMAGIVF
241: AKMTRAKQRA QTLLFSKHAV ICQRDGTLSL MFRVGDMRKS HIIGAGVRAQ LIRTKSTKEG
301: EVMTQYFTEL EIGTDDSGSD LFFIWPMVIE HKIDENSPLY NLNATDMLQD KFEIVVILEG
361: TVESTGQSTQ ARSSYINTEI LWGHRFDPVV LYNKDLQAYE IDYARFNETT QVDTPLCSAR
421: ELNEIYKIQE GFRTPETTFT MRQLSHNHSD QAS