1.A.4.1.10
Trp-2 channel; controls nicotine-dependent behavior (Xiao and Xu 2009). The TRPC orthologues TRP-1 and -2 genetically
complement the loss of syndecan by suppressing neuronal guidance and locomotory defects related to
increases in neuronal calcium levels. The widespread and conserved syndecan-TRPC axis therefore fine
tunes cytoskeletal organization and cell behavior (Gopal et al. 2015).
|
| Accession Number: | G5EE02 |
|---|
| Protein Name: | Protein TRP-2, isoform a |
|---|
| Length: | 816 |
|---|
| Molecular Weight: | 94781.00 |
|---|
| Species: | Caenorhabditis elegans [6239] |
|---|
| Number of TMSs: | 6 |
|---|
| Substrate |
calcium(2+) |
|---|
1: MTSSEASEFR MIEDDDDVSN NVTWTESDNS RLREKQFLLS CERGDIGSVR KLLAGISTET
61: FNINCLDPLG RNALLIAIEN ENIEMIELLL DHNIETGDAI LYAIGEENVE AVEIIVEHLE
121: KMDKFDSERQ GVEITEHSAF TPDITPIVLA AHKDNYECIK LFLDKKGTVP HPHDVRCSCP
181: ECYVAREEDS LRLSRSRINA YRALTSPSLI CLSARDPILY AFELSWELKR LSFIENEFRT
241: DYEELSQKCQ KFCVHMLDQV RGSKELEVVL NHTTNAWHDV TSANYGNPEK LARLKLAIQL
301: SQKRFVAHPN CQQLLLDIWY EGVESVRCTN FIYKLIFYIL GMLSFPLFSL VYLLAPHSSM
361: GQFAKKPFIK FLSHSGSYIF FLILLIMASQ RMNVIDNILR TDDVDRKETR GPPPTIIECA
421: IFLWVLGLIW VEIKQLWECG LYNYCRNLWN ILDFITNSLY LCTTALRVVA YVQVEQEALR
481: ANSVHIARHL PRRDWDAWDP TLLSECFFAT ANIFSSLKLV HIFTVSPHLG PLKISLGRMV
541: IDIVKFFMVY ALVLFAFACG LNQLLWYYAS MRQNECNLYE QYKNEKSLSY KYEHLKESCD
601: DKYKSCSSIY HTAETLFWAL FGLVDLTHFR LKEDHFLSEW TGKTIFGSYC CCSIIVLLNM
661: LIAMMSNSYQ YISDQADIEW KFARSRLFLE YFDDTATLPP PFNIVPSPKS IYYCLHYLTK
721: KLCNCTKLQQ PSKQKSMRNQ KILRSVNDRE NNYRKTIIHA EQLQVELEQS ESESFTSFKI
781: QINRYYTSRC YPVTCVEQKI AASKTSPYEF RHLQSQ