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1.A.4.1.7
Short transient receptor channel 5 (TrpC5 or Htrp5) (transports Ca2+ and Sr2+ in the presence of Orai1 and STIM1 (TC# 1.A.52.1.1) (Ma et al., 2008). It is a cold-transducer in the peripheral nervous system (Zimmermann et al., 2011). A small-molecule inhibitor suppresses progressive kidney disease in rats (Zhou et al. 2017).  ORAI and TRP, and the transmembrane Ca2+ sensors, stromal interaction molecules (STIMs), are involved in thrombosis and thrombo-inflammation in platelets and immune cells. Disregulated store-operated Ca2+ (SOCE) fluxes in platelets and immune cells are responsible, and the potential of SOCE inhibition as a therapeutic option to prevent or treat arterial thrombosis as well as thrombo-inflammatory disease states such as ischemic stroke have been considered (Mammadova-Bach et al. 2019).

Accession Number:Q9UL62
Protein Name:TrpC5
Length:973
Molecular Weight:111412.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate strontium(2+), calcium(2+)

Cross database links:

RefSeq: NP_036603.1   
Entrez Gene ID: 7224   
Pfam: PF00520    PF08344   
OMIM: 300334  gene
KEGG: hsa:7224   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005515 F:protein binding
GO:0015279 F:store-operated calcium channel activity
GO:0006816 P:calcium ion transport
GO:0007399 P:nervous system development
GO:0055085 P:transmembrane transport

References (9)

[1] “Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca(2+) entry channel.”  Sossey-Alaoui K.et.al.   10493832
[2] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “A novel capacitative calcium entry channel expressed in excitable cells.”  Philipp S.et.al.   9687496
[5] “Subunit composition of mammalian transient receptor potential channels in living cells.”  Hofmann T.et.al.   12032305
[6] “MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.”  Lussier M.P.et.al.   15757897
[7] “Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes.”  Kinoshita-Kawada M.et.al.   15895247
[8] “RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC.”  Lussier M.P.et.al.   17850865
[9] “The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5.”  Miehe S.et.al.   20164195

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MAQLYYKKVN YSPYRDRIPL QIVRAETELS AEEKAFLNAV EKGDYATVKQ ALQEAEIYYN 
61:	VNINCMDPLG RSALLIAIEN ENLEIMELLL NHSVYVGDAL LYAIRKEVVG AVELLLSYRR 
121:	PSGEKQVPTL MMDTQFSEFT PDITPIMLAA HTNNYEIIKL LVQKRVTIPR PHQIRCNCVE 
181:	CVSSSEVDSL RHSRSRLNIY KALASPSLIA LSSEDPILTA FRLGWELKEL SKVENEFKAE 
241:	YEELSQQCKL FAKDLLDQAR SSRELEIILN HRDDHSEELD PQKYHDLAKL KVAIKYHQKE 
301:	FVAQPNCQQL LATLWYDGFP GWRRKHWVVK LLTCMTIGFL FPMLSIAYLI SPRSNLGLFI 
361:	KKPFIKFICH TASYLTFLFM LLLASQHIVR TDLHVQGPPP TVVEWMILPW VLGFIWGEIK 
421:	EMWDGGFTEY IHDWWNLMDF AMNSLYLATI SLKIVAYVKY NGSRPREEWE MWHPTLIAEA 
481:	LFAISNILSS LRLISLFTAN SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF 
541:	YYETRAIDEP NNCKGIRCEK QNNAFSTLFE TLQSLFWSVF GLLNLYVTNV KARHEFTEFV 
601:	GATMFGTYNV ISLVVLLNML IAMMNNSYQL IADHADIEWK FARTKLWMSY FDEGGTLPPP 
661:	FNIIPSPKSF LYLGNWFNNT FCPKRDPDGR RRRRNLRSFT ERNADSLIQN QHYQEVIRNL 
721:	VKRYVAAMIR NSKTHEGLTE ENFKELKQDI SSFRYEVLDL LGNRKHPRSF STSSTELSQR 
781:	DDNNDGSGGA RAKSKSVSFN LGCKKKTCHG PPLIRTMPRS SGAQGKSKAE SSSKRSFMGP 
841:	SLKKLGLLFS KFNGHMSEPS SEPMYTISDG IVQQHCMWQD IRYSQMEKGK AEACSQSEIN 
901:	LSEVELGEVQ GAAQSSECPL ACSSSLHCAS SICSSNSKLL DSSEDVFETW GEACDLLMHK 
961:	WGDGQEEQVT TRL