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1.A.8.4.1
Intracellular endoplasmic reticulum (ER)-localized Aquaporin 11 (Aqp11, AqpX1) water channel (important for the development of kidney proximal tubules; disruption produces neonatally fatal polycystic kidneys (Ishibashi 2006). Has a positively charged C-terminal amino acid cluster similar to the di-lysine motif (-KKXX) for ER retention (Nozaki et al., 2008)). In the horse, AQP3 and AQP11 are involved in the resilience of stallion sperm to withstand cryopreservation (Bonilla-Correal et al. 2017).

Accession Number:Q8NBQ7
Protein Name:Aqp11
Length:271
Molecular Weight:30203.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate molecule, water

Cross database links:

RefSeq: NP_766627.1   
Entrez Gene ID: 282679   
Pfam: PF00230   
OMIM: 609914  gene
KEGG: hsa:282679   

Gene Ontology

GO:0009986 C:cell surface
GO:0016021 C:integral to membrane
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (2)

[1] “Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”  Otsuki T.et.al.   16303743
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MSPLLGLRSE LQDTCTSLGL MLSVVLLMGL ARVVARQQLH RPVAHAFVLE FLATFQLCCC 
61:	THELQLLSEQ HPAHPTWTLT LVYFFSLVHG LTLVGTSSNP CGVMMQMMLG GMSPETGAVR 
121:	LLAQLVSALC SRYCTSALWS LGLTQYHVSE RSFACKNPIR VDLLKAVITE AVCSFLFHSA 
181:	LLHFQEVRTK LRIHLLAALI TFLVYAGGSL TGAVFNPALA LSLHFMCFDE AFPQFFIVYW 
241:	LAPSLGILLM ILMFSFFLPW LHNNHTINKK E