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1.A.8.8.29
Aquaporin/glycerol transporter of 294 aas and 6 TMSs.  Tandem duplication (TD) was the major mechanism of gene expansion in echinoderms and hemichordates, which, together with whole genome duplications (WGD) in the chordate lineage, continued to shape the genomic repertoires in craniates. Molecular phylogenies indicated that Aqp3-like and Aqp13-like channels were the probable stem subfamilies in craniates, with WGD generating Aqp9 and Aqp10 in gnathostomes but Aqp7 arising through TD in Osteichthyes (Yilmaz et al. 2020).

Accession Number:B5THM7
Protein Name:Aquaporin protein
Length:294
Molecular Weight:31715.00
Species:Saccoglossus kowalevskii (Acorn worm) [10224]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAPAKSVVAE VCDIRCCQEL RFWRAVAAEM LGTFLFLFIL LSSTISWNDQ TPTILQISFA 
61:	AGLAIATLVQ CFGHISGGHL NPAVTVAMLF TGKIGVFKSL FYIIAQCVGA IGGAALVFGV 
121:	TPEEVRGNMG ANVLNAYVTA IQGFGIEFTL TFILVFTVFA TTDERNEISG SKPLAIGIAV 
181:	IIAHLVGIGY TSVGINPART LGASVMMKMF DDHWVFWAGP LGGGVAAGWI YVFTFGRQFD 
241:	TEKRETESEK YTEHHKYLES ISMDSANDRS TFVVEDAPGV KVDTVNLSNE VTTL