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Accession Number: | P55087 |
Protein Name: | Aqp4 |
Length: | 323 |
Molecular Weight: | 34830.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 6 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | water |
Cross database links:
RefSeq: | NP_001641.1 NP_004019.1 |
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Entrez Gene ID: | 361 |
Pfam: | PF00230 |
OMIM: |
600308 gene |
KEGG: | hsa:361 |
Gene Ontology
GO:0005737
C:cytoplasm
GO:0009897
C:external side of plasma membrane
GO:0005887
C:integral to plasma membrane
GO:0005372
F:water transmembrane transporter activity
GO:0071346
P:cellular response to interferon-gamma
GO:0007588
P:excretion
GO:0050891
P:multicellular organismal water homeostasis
GO:0007399
P:nervous system development
GO:0055085
P:transmembrane transport
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References (4)[1] “cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units.” Yang B.et.al. 7559426 [2] “A water channel closely related to rat brain aquaporin 4 is expressed in acid- and pepsinogen-secretory cells of human stomach.” Misaka T.et.al. 8601457 | |
Structure: | |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MSDRPTARRW GKCGPLCTRE NIMVAFKGVW TQAFWKAVTA EFLAMLIFVL LSLGSTINWG 61: GTEKPLPVDM VLISLCFGLS IATMVQCFGH ISGGHINPAV TVAMVCTRKI SIAKSVFYIA 121: AQCLGAIIGA GILYLVTPPS VVGGLGVTMV HGNLTAGHGL LVELIITFQL VFTIFASCDS 181: KRTDVTGSIA LAIGFSVAIG HLFAINYTGA SMNPARSFGP AVIMGNWENH WIYWVGPIIG 241: AVLAGGLYEY VFCPDVEFKR RFKEAFSKAA QQTKGSYMEV EDNRSQVETD DLILKPGVVH 301: VIDVDRGEEK KGKDQSGEVL SSV