| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
1.A.85.1.1 | The human poliovirus 2B viroporin (from the polyprotein). The 97 residue 2B viroporin consists of residues 1031-1127 in the polyprotein. in vitro and in vivo translation-glycosylation compatible with the translocon-mediated insertion of the 2B product into the ER membrane as a double-spanning integral membrane protein with an N-/C-terminal cytoplasmic orientation has been reported (Agirre et al. 2008; Martínez-Gil et al. 2011). The in vitro translation of several truncated versions of the 2B protein suggests that the two hydrophobic regions cooperate to insert into the ER-derived microsomal membranes. 2B is specific for Ca2+ and plays a role in particle production and cell lysins (Scott and Griffin 2015). The 3A viroporin of poliovirus transports monovalent cations (Hyser and Estes 2015). It and the VP4 viroporin are encoded within the viral polyprotein of 2209 aas (P03300). | Viruses |
Orthornavirae, Pisuviricota | 2B viroporin of Human poliovirus 1 (Q9Q280) |
|
1.A.85.1.2 | 2B protein (99 aas) derived from the polyprotein of human coxsackie virus (Patargias et al., 2009). It has specificy for Ca2+ and functions in particle production and cell lysis (Scott and Griffin 2015). | Viruses |
Orthornavirae, Pisuviricota | B2 capsid protein of the human coxsackie virus. (Q5MP79) |
|
1.A.85.1.3 | Echovirus E30 polyprotein (128 aas; fragment). An intracellular (endomembrane) pore-forming peptide toxin which induces membrane permeability due to two consecutive hydrophobic segments that may form an α-helix-turn-α-helix hairpin membrane anchor that provides the basis for oligomeric pore formation (Sánchez-Martínez et al. 2012). This protein is derived from the Coxsackle virus B2 protein of 2187 aas (Q9YLG5) and may interact with a Ryanodine receptor (Schilling et al. 2013). | Viruses |
Orthornavirae, Pisuviricota | Polyprotein, including the 100 aa viroporin of human enterovirus (echovirus E30) |
|
1.A.85.1.4 | Polyprotein of 2333 aas (includes the viroporin peptide, NS2B). Viroporin activity for the NS2B protein has been demonstrated (Ao et al. 2015). | Viruses |
Orthornavirae, Pisuviricota | Viroporin-containing polyprotein of foot-and-mouth disease virus |
|
1.A.85.1.5 | Rat picornavirus 2B protein of 116 as and 2 TMSs, a membrane active peptide (Sánchez-Martínez et al. 2012). It has viroporin-like activity which affects the biological function of the membrane, regulates cell death, and affects the host immune response (Li et al. 2019). | Viruses |
Orthornavirae, Pisuviricota | 2B protein of rat picornavirus |
|
1.A.85.1.6 | The genome polyprotein of 2292 aas encoding the viroporin of Encephalomyocarditis virus (Ito et al. 2012). | Viruses |
Orthornavirae, Pisuviricota | Polyprotein of Encephalomyocarditis virus |
|
1.A.85.1.7 | Human rhinovirus 1A 2B protein of 2157 aas | Viruses |
Orthornavirae, Pisuviricota | 2B of human rhionvirus 1A |
|
1.A.85.1.8 | The Viroporin, protein 2B, of 154 aas and 3 TMSs where TMS 2 provides the channel activity. Transports cations, Ca2+ and small molecules (Gladue et al. 2018). Present within the Polyprotein of 2332 aas. | Viruses |
Orthornavirae, Pisuviricota | Poly protein of foot-and-mouth disease virus (FMDV) |
|
1.A.85.1.9 | Nonstructural protein, NS2B, partial of 122 aas and 2 TM | Viruses |
Orthornavirae, Pisuviricota | NS2B of Encephalomyocarditis virus |