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1.A.85.1.1
The human poliovirus 2B viroporin (from the polyprotein). The 97 residue 2B viroporin consists of residues 1031-1127 in the polyprotein.  in vitro and in vivo translation-glycosylation compatible with the translocon-mediated insertion of the 2B product into the ER membrane as a double-spanning integral membrane protein with an N-/C-terminal cytoplasmic orientation has been reported (Agirre et al. 2008; Martínez-Gil et al. 2011). The in vitro translation of several truncated versions of the 2B protein suggests that the two hydrophobic regions cooperate to insert into the ER-derived microsomal membranes. 2B is specific for Ca2+ and plays a role in particle production and cell lysins (Scott and Griffin 2015). The 3A viroporin of poliovirus transports monovalent cations (Hyser and Estes 2015). It and the VP4 viroporin are encoded within the viral polyprotein of 2209 aas (P03300).

Accession Number:Q9Q280
Protein Name:Enterovirus polypeptide
Length:2209
Molecular Weight:246046.00
Species:Human poliovirus 1 [12080]
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate monoatomic monocation

Cross database links:

Pfam: PF08727    PF00548    PF02226    PF00947    PF01552    PF00680    PF00073    PF00910   

Gene Ontology

GO:0044161 C:host cell cytoplasmic vesicle
GO:0033644 C:host cell membrane
GO:0016020 C:membrane
GO:0019028 C:viral capsid
GO:0005524 F:ATP binding
GO:0004197 F:cysteine-type endopeptidase activity
GO:0003723 F:RNA binding
GO:0003724 F:RNA helicase activity
GO:0003968 F:RNA-directed RNA polymerase activity
GO:0005198 F:structural molecule activity
GO:0006508 P:proteolysis
GO:0018144 P:RNA-protein covalent cross-linking
GO:0006410 P:transcription, RNA-dependent
GO:0019079 P:viral genome replication

References (2)

[1] “Evolution of poliovirus type I during 5.5 years of prolonged enteral replication in an immunodeficient patient.”  Bellmunt A.et.al.   10600590
[2] “Role of myristoylation of poliovirus capsid protein VP4 as determined by site-directed mutagenesis of its N-terminal sequence.”  Marc D.et.al.   2555183

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGAQVSSQKV GAHENSNKAS GGSTINYTTI NYYRDSASNA ASKQDFSQDP SKFTEPIKDV 
61:	LIKTAPTLNS PNIEACGYSD RVMQLTLGNS TITTQEAANS VVAYGRWPEY LRDSEANPVD 
121:	QPTEPDVAAC RFYTLDTVSW TKESRGWWWK LPDALRDMGL FGQNMYYHYL GRSGYTVHVQ 
181:	CNASKFHQGA LGVFAVPEMC LAGDSNTTTM HTSYQNANPG EKGGTFTGTF TPDTNQTSPT 
241:	RRFCPVDYLF GNGTLLGNAF VFPHQIINLR TNNCATLVLP YVNSLSIDSM VKHNNWGIAI 
301:	LPLAPLNFAS ESSTEIPITL TIAPMCCEFN GLRNITLPRL QGLPVMNTPG SNQYLTADNF 
361:	QSPCALPEFD VTPPIDIPGE VKNMMELAEI DTMIPLNLSA TKKNTMDMYR VQLNDNPHTD 
421:	KPILCLSLSP ASDPRLSHTM LGEVLNYYTH WAGSLKFTFL FCGSMMATGK LLVSYAPPGA 
481:	DPPKRRKEAM LGTHVIWDIG LQSSCTMVVP WISNTTYRQT TNDSFTEGGY VSVFYQTRVV 
541:	VPLSTPREMD ILGFVSACND FSVRLLRDTT HIGQSALAQG IGQMLESMID NTVRETAGAA 
601:	TSRNALPNTE ASGSAHSKEI PALTAVETGA TNPLVPSDTV QTRHVIQHRS RSESSIESFF 
661:	ARGACVSIIT VDNSASSAKN DRLFAVWKIT YKDTVQLRRK LEFFTYSRFD MEFTFVVTAN 
721:	FTETNNGHAL NQVYQIMYVP PGAPVPAKWD DYTWQTSSNP SIFYTYGAAP ARISIPYVGI 
781:	ANAYSHFYDG FSKVPLKDQS AALGDSLYGA ASLNDFGVLA VRVVNDHNPT KVTSKIRVYL 
841:	KPKHIRVWCP RPPRAVAYYG PGVDYKDGTL TPLSTKDLTT YGFGHQNKAV YTAGYKICNY 
901:	HLATQEDLQN AVSTMWDRDL LVTESKAQGT DTIARCNCKA GVYYCESRRK YYPVSFIGPT 
961:	FQYMEANGYY PARYQSHILI GHGFASPGDC GGILRCHHGV IGIITAGGEG LVAFADIRDL 
1021:	YAYEEEAMEQ GITNYIESLG AAFGSGFTQQ IGDKVTELTN MVTSTITEKL LKNLIKIISS 
1081:	LVIITRNYED TTTVLATLAL LGCDVSPWQW LKKKACDILE IPYVIKQGDS WLKKFTEACN 
1141:	AAKGLEWVSN KISKFIDWLK EKIIPQARDK LEFVTRLKQL EMLENQISTI HQSCPSQEHQ 
1201:	EVLFNNVRWL SIQSKRFAPL YAMEAKRIQK LEHTINNYIQ FKSKHRIEPV CLLVHGSPGT 
1261:	GKSVATNLIA RAIAERENTS TYSLPPDPSH FDGYKQQGVV IMDDLNQNPD GADMKLFCQM 
1321:	VSTVEFIPPM ASLEEKGILF TSNYVLASTN SSRITPPTVA HSDALTRRFA FDMDIQVMSE 
1381:	YFRDGKLDMT MATEMCKNCH QPANFKRCCP LVCGKAIQLM DKSSRVRYSV DQITTMIVNE 
1441:	RNRRSNIGNC MEALFQGPIQ YKDLKIDIKT SPPPECINDL LQAVDSQEVR NYCEKKGWIV 
1501:	NITSQVQTER NINRAMTILQ AVTTFAAVAG VVYVMYKLFA GHQGAYTGLP NKKPNVPTIR 
1561:	TAKVQGPGFD YAVAMAKRNI VTATTSKGEF TMLGIHDNVA ILPTHASPGE SIVIDGKEVE 
1621:	ILDAKALEDQ AGTNLEITII TLRRNEKFRD IRPHIPTQIT ETNDGVLIVN TSKYPNMFVP 
1681:	VGAVTEQGYL NLGGRQTART LMYNFPTRAG QCGGVITCTG KVIGMHVGGN GSHGFAAALK 
1741:	RSYFTQSQGE IQWMRPSKEV GYPIINAPSK TKLEPSAFHY VFEGVKEPAV LTKSDPRLKT 
1801:	DFEEAIFSKY VGNKITEVDE YMKEAVDHYA GQLMALDINT EQMCLEDAMY GTDGLEALDL 
1861:	STSAGYPYVA MGKKKRDILN KQTRDTKEMQ RLLDTYGINL PLVTYVKDEL RSKAKVEQGK 
1921:	SRLIEASSLN DSVAMRMAFG NLYAAFHKNP GVITGSAVGC DPDLFWSKIP VLMEERLFAF 
1981:	DYTGYDASLS PAWFEALKMV LEKIGFGDRV DYIDYLNHSH HLYKNKTYCV KGGMPSGCSG 
2041:	TSIFNSMINN LIIRTLLLKT YKGIDLDHLK MIAYGDDVIA SYPHEVDASL LAQSGKDYGL 
2101:	TMTPADKSAT FETVTWENVT FLKRFFRADE KYPFLVHPVM PMKEIHESIR WTKDPRNTQD 
2161:	HVRSLCLLAW HNGEEEYNKF LAKIRSVPIG RALLLPEYST LYRRWLDSF