1.B.98. The Cell Wall (Outer Membrane) Porin-2 (PorA2) Family
This family (DUF3068; pfam11271) includes members of about 375 aas with two very hydrophobic TMSs at the N- and C-termini. The PorA of Corynebacterium amycolatum forms water-filled channels that favor the permeation of cations (Dörner et al. 2009; Soltan Mohammadi et al. 2013). The 'cell-wall' channel is wide and water-filled and has a narrow selectivity for cations (Dörner et al. 2009).
References associated with 1.B.98 family:
Dörner, U., B. Schiffler, M.A. Lanéelle, M. Daffé, and R. Benz. (2009). Identification of a cell-wall channel in the corynemycolic acid-free Gram-positive bacterium Corynebacterium amycolatum. Int Microbiol 12: 29-38. 19440981
Gupta, K.R., C.M. Gwin, K.C. Rahlwes, K.J. Biegas, C. Wang, J.H. Park, J. Liu, B.M. Swarts, Y.S. Morita, and E.H. Rego. (2022). An essential periplasmic protein coordinates lipid trafficking and is required for asymmetric polar growth in mycobacteria. Elife 11:. 36346214
Piselli, C., L. Benier, C. Koy, M.O. Glocker, and R. Benz. (2022). Cell wall channels of Rhodococcus species: identification and characterization of the cell wall channels of Rhodococcus corynebacteroides and Rhodococcus ruber. Eur Biophys. J. 51: 309-323. 35567623
Soltan Mohammadi, N., S. Mafakheri, N. Abdali, I. Bárcena-Uribarri, A. Tauch, and R. Benz. (2013). Identification and characterization of the channel-forming protein in the cell wall of Corynebacterium amycolatum. Biochim. Biophys. Acta. 1828: 2574-2582. 23811360