| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
1.C.35.1.1 | Amoebapore A | Eukaryota |
Entamoeba | Amoebapore A of Entamoeba histolytica |
|
1.C.35.1.2 | Amoebapore B | Eukaryota |
Entamoeba | Amoebapore B of Entamoeba histolytica |
|
1.C.35.1.3 | Amoebapore C | Eukaryota |
Entamoeba | Amoebapore C of Entamoeba histolytica |
|
1.C.35.1.4 | Nonpathogenic pore-forming peptide precursor, APNP | Eukaryota |
Entamoeba | APNP of Entamoeba histolytica |
|
1.C.35.1.5 | Pore-forming protein-like protein of 79 aas, saposin B type, SapB | Eukaryota |
Metazoa | SapB of Steinernema carpocapsae (Entomopathogenic nematode) |
|
1.C.35.2.1 | Cerebroside sulfate activator protein, CSAP or prosaposin (PSAP, GLBA, SAP1) of 524 aas. Saposin A, B, C and D are derived from prosaposin by proteolysis. Saposin-A and C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase and galactosylceramide by beta-galactosylceramidase. Saposin-C apparently acts by combining with the enzyme and acidic lipids to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A, GM1 gangliosides by β-galactosidase and globotriaosylceramide by α-galactosidase A. Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator. Prosaposin behaves as a myelinotrophic and neurotrophic factor; these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling (Hiraiwa et al. 1999). | Eukaryota |
Metazoa | CSAP of Homo sapiens |
|
1.C.35.2.2 | Saposin-like protein (Saplip C; SalA) of 157 aas. Important for lipid interactions and lysosomal degradation of several sphingolipids (Vaccaro et al. 1999). | Eukaryota |
Dictyosteliida | Saplip C of Dictyostelium discoideum (Slime mold) |
|
1.C.35.2.3 | Saposin of 254 aas and 1 N-terminal TMS (Hao et al. 2010). | Eukaryota |
Metazoa | Saposin of Steinernema carpocapsae (Entomopathogenic nematode) |
|
1.C.35.3.1 | Antimicrobial natural killer cell lysin, NK-lysin of 129 aas. NK-lysin is involved in the inducible cytotoxicity of T and NK cells (Andersson et al. 1996). | Eukaryota |
Metazoa | NK lysin of Sus scrofa |
|
1.C.35.3.2 | Granulosin of 145 aas and 1 TMS. Functions probably by pore-formation by natural killer (NK) and T lympocyces to combat intracellular parasites, both bacterial and eukaryotic (Dotiwala et al. 2016). | Eukaryota |
Metazoa | Granulosin of Homo sapiens |
|
1.C.35.4.1 | Countin | Eukaryota |
Dictyosteliida | Countin of Dictyostelium discoideum |