| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
1.C.35.1.1 | Amoebapore A | Eukaryota |
Evosea | Amoebapore A of Entamoeba histolytica |
|
1.C.35.1.2 | Amoebapore B | Eukaryota |
Evosea | Amoebapore B of Entamoeba histolytica |
|
1.C.35.1.3 | Amoebapore C | Eukaryota |
Evosea | Amoebapore C of Entamoeba histolytica |
|
1.C.35.1.4 | Nonpathogenic pore-forming peptide precursor, APNP | Eukaryota |
Evosea | APNP of Entamoeba histolytica |
|
1.C.35.1.5 | Pore-forming protein-like protein of 79 aas, saposin B type, SapB | Eukaryota |
Metazoa, Nematoda | SapB of Steinernema carpocapsae (Entomopathogenic nematode) |
|
1.C.35.2.1 | Cerebroside sulfate activator protein, CSAP or prosaposin (PSAP, GLBA, SAP1) of 524 aas. Saposin A, B, C and D are derived from prosaposin by proteolysis. Saposin-A and C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase and galactosylceramide by beta-galactosylceramidase. Saposin-C apparently acts by combining with the enzyme and acidic lipids to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A, GM1 gangliosides by β-galactosidase and globotriaosylceramide by α-galactosidase A. Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator. Prosaposin behaves as a myelinotrophic and neurotrophic factor; these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling (Hiraiwa et al. 1999). | Eukaryota |
Metazoa, Chordata | CSAP of Homo sapiens |
|
1.C.35.2.2 | Saposin-like protein (Saplip C; SalA) of 157 aas. Important for lipid interactions and lysosomal degradation of several sphingolipids (Vaccaro et al. 1999). | Eukaryota |
Evosea | Saplip C of Dictyostelium discoideum (Slime mold) |
|
1.C.35.2.3 | Saposin of 254 aas and 1 N-terminal TMS (Hao et al. 2010). | Eukaryota |
Metazoa, Nematoda | Saposin of Steinernema carpocapsae (Entomopathogenic nematode) |
|
1.C.35.3.1 | Antimicrobial natural killer cell lysin, NK-lysin of 129 aas. NK-lysin is involved in the inducible cytotoxicity of T and NK cells (Andersson et al. 1996). Recombinant NK-lysin inhibits hepatocellular carcinoma metastasis by downregulating FKBP3 and inhibiting oxidative phosphorylation and glycolysis (Fan et al. 2023). | Eukaryota |
Metazoa, Chordata | NK lysin of Sus scrofa |
|
1.C.35.3.2 | Granulosin of 145 aas and 1 TMS. Functions probably by pore-formation by natural killer (NK) and T lympocyces to combat intracellular parasites, both bacterial and eukaryotic (Dotiwala et al. 2016). | Eukaryota |
Metazoa, Chordata | Granulosin of Homo sapiens |
|
1.C.35.3.3 | Antimicrobial peptide NK-lysin-like protein of 147 aas and 1 N-terminal TMS. It has two sequential domains, Saposin A (SapA) and SapB. | Eukaryota |
Metazoa, Chordata | NK-lysin-like protein of Grus japonensis (Red-crowned crane) |
|
1.C.35.3.4 | Antimicrobial peptide NK-lysin isoform X1 of 240 aas and 1 N-terminal TMS. | Eukaryota |
Metazoa, Chordata | NK-lysin of Taeniopygia guttata (zebra finch) |
|
1.C.35.3.5 | Uncharacterized protein of 268 aas and 2 TMSs, one N-terminal and one at about residue 140. | Eukaryota |
Metazoa, Chordata | UP of Albula glossodonta |
|
1.C.35.4.1 | Countin of 258 aas with 1 N-terminal TMS. | Eukaryota |
Evosea | Countin of Dictyostelium discoideum |
|
1.C.35.4.2 | Countin3 of 237 aas and 1 or 2 TMSs, one at the N-terminus and the second at about residue 80. | Eukaryota |
Evosea | Countin3 of Cavenderia fasciculata |
|
1.C.35.4.3 | Uncharacterized protein of 413 aas and 4 clear peaks of hydrophobicity between residues 50 and 200. | Eukaryota |
Metazoa, Rotifera | UP of Rotaria sp. Silwood1 |
|
1.C.35.4.4 | Uncharacterized protein of 120 aas and possibly one TMS near the N-terminus. | Eukaryota |
Metazoa, Bryozoa | UP of Bugula neritina |
|
1.C.35.4.5 | Uncharacterized protein of 176 aas and possibly 2 TMSs at about residies 80 and 120. | Eukaryota |
Heterolobosea | UP of Naegleria fowleri |
|
1.C.35.4.6 | Uncharacterized protein of 237 aas and one N-terminal TMS. | Eukaryota |
Metazoa, Mollusca | UP of Lottia gigantea (owl limpet) |