Histatin 3 precursor of 51 aas and 1 N-terminal TMS.  Histatins are salivary proteins that are major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C. albicans and C. neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P. gingivalis (Gusman et al. 2001; Tsai et al. 1996). The His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9. It may kill cells by volume dysregulation and ion imbalance triggered by osmotic stress (Puri and Edgerton 2014). Histatins also promote wound healing (Torres et al. 2018).