1.C.8.1.4
Non-toxic nonhemagglutinin type C of 1196 aas. Assembles with botulinum neurotoxin type C
(BoNT/C) and protects it against pH-mediated inactivation or protease
activity at pH 2.6 (the pH of the animal gastrointestinal tract) but not
at pH 6.0. The non-toxic component is necessary to maintain toxicity.
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| Accession Number: | P46081 |
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| Protein Name: | Non-toxic nonhemagglutinin type C |
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| Length: | 1196 |
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| Molecular Weight: | 138741.00 |
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| Species: | Clostridium botulinum C phage [12336] |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
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1: MDINDDLNIN SPVDNKNVVI VRARKTNTFF KAFKVAPNIW VAPERYYGEP LDIAEEYKLD
61: GGIYDSNFLS QDSERENFLQ AIIILLKRIN NTISGKQLLS LISTAIPFPY GYIGGGYSSP
121: NIFTFGKTPK SNKKLNSLVT STIPFPFGGY RETNYIESQN NKNFYASNII IFGPGSNIVE
181: NNVIYYKKND AENGMGTMAE IVFQPLLTYK YNKFYIDPAM ELTKCLIKSL YFLYGIKPSD
241: NLVVPYRLRT ELDNKQFSQL NIIDLLISGG VDLEFINTNP YWFTNSYFPN SIKMFEKYKN
301: IYKTEIEGNN AIGNDIKLRL KQKFQINVQD IWNLNLNYFC QSFNSIIPDR FSNALKHFYR
361: KQYYTMDYTD NYNINGFVNG QINTKLPLSN KNTNIISKPE KVVNLVNENN ISLMKSNIYG
421: DGLKGTTEDF YSTYKIPYNE EYEYRFNDSD NFPLNNISIE EVDSIPEIID INPYKDNSDN
481: LVFTQITSMT EEVTTHTALS INYLQAQITN NENFTLSSDF SKVVSSKDKS LVYSFLDNLM
541: SYLETIKNDG PIDTDKKYYL WLKEVFKNYS FDINLTQEID SMCGINEVVL WFGKALNILN
601: TSNSFVEEYQ DSGAISLISK KDNLREPNIE IDDISDSLLG LSFKDLNNKL YEIYSKNIVY
661: FKKIYFSFLD QWWTEYYSQY FELICMAKQS ILAQESLVKQ IVQNKFTDLS KASIPPDTLK
721: LIRETTEKTF IDLSNESQIS MNRVDNFLNK ASICVFVEDI YPKFISYMEK YINNINIKTR
781: EFIQRCTNIN DNEKSILINS YTFKTIDFKF LDIQSIKNFF NSQVEQVMKE ILSPYQLLLF
841: ASKGPNSNII EDISGKNTLI QYTESIELVY GVNGESLYLK SPNETIKFSN KFFTNGLTNN
901: FTICFWLRFT GKNDDKTRLI GNKVNNCGWE IYFEDNGLVF EIIDSNGNQE SVYLSNIIND
961: NWYYISISVD RLKDQLLIFI NDKNVANVSI DQILSIYSTN IISLVNKNNS IYVEELSVLD
1021: NPITSEEVIR NYFSYLDNSY IRDSSKSLLE YNKNYQLYNY VFPETSLYEV NDNNKSYLSL
1081: KNTDGINISS VKFKLINIDE SKVYVQKWDE CIICVLDGTE KYLDISPENN RIQLVSSKDN
1141: AKKITVNTDL FRPDCITFSY NDKYFSLSLR DGDYNWMICN DNNKVPKGAH LWILES