Botulinum neurotoxin types A-G.  Poly(amindo)amine (PAMAM) detrimers block activity (Förstner et al. 2014).  BoNTs inhibit synaptic exocytosis; intoxication requires the di-chain protein to undergo conformational changes in response to pH and redox gradients across the endosomal membrane with consequent formation of a protein-conducting channel by the heavy chain (HC) that translocates the light chain (LC) protease into the cytosol, colocalizing it with the substrate SNARE proteins (Montal 2009). Botulinum toxin type A inhibits salivary secretion, possibly by alterring RNA synthesis (Mao et al. 2020).