| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
1.C.99.1.1 | Cation (K+, Na+)-selective pore-forming Orf8a (Sars8a) peptide of 39 aas and 1 N-terminal TMS (Hsu et al. 2015, Scott and Griffin 2015). Because of its pore forming capacity, this protein could also be assigned to TC subclass 1.A (Barrantes 2021). | Viruses |
Orthornavirae, Pisuviricota | Orf8a of severe acute respiratory syndrome causing corona virus (SARS-CoV) (Q7TA23) |
|
1.C.99.1.2 | Pore-forming protein of 122 aas with 1 N-terminal TM | Viruses |
Orthornavirae, Pisuviricota | Pore-former of Bat β-coronavirus |
|
1.C.99.1.3 | Non structural protein 8 of 121 aas and 1 N-terminal TM | Viruses |
Orthornavirae, Pisuviricota | Protein 8 of Bat coronavirus 279/2005 (BtCoV) |
|
1.C.99.1.4 | ORF8 protein of 121 aas and 1 N-terminal TMS. Orf8 is a short 29-amino-acid single-passage transmembrane peptide that forms cation-selective channels when assembled in lipid bilayers (Barrantes 2021). A cell-based system combined with flow cytometry can be used to evaluate antibody responses against SARS-CoV-2 transmembrane proteins in patients with COVID-19 (Martin et al. 2022). | Viruses |
Orthornavirae, Pisuviricota | ORF8 of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
|
1.C.99.1.5 | Uncharaacterized protein, Sars8b of 84 aas and 0 TMSs. This protein may be N-terminally truncated. | Viruses |
Orthornavirae, Pisuviricota | Sars8b of Severe acute respiratory syndrome-related coronavirus (SARS) |
|
1.C.99.2.1 | Uncharacterized protein of 101 aas and 1 or 2 TMSs, with one TMS at the N-terminus, and possibly another at the C-terminus. | Viruses |
Orthornavirae, Pisuviricota | UP of SARS coronavirus WH20 |
|
1.C.99.2.2 | Orf7a of 121 aas and 2 or 3 TMSs, one at the N-terminus, one at the C-terminus, and a peak of moderate hydrophobicity in the middle. N-terminal fragments of 29 aas, 39 aas and 43 aas can be found in the NCBI protein database (Acc# QIG55990, QIS30140, and QIZ64621, respectively). Bone marrow stromal antigen 2 (BST-2; tetherin) is an antiviral response protein that inhibits transport of viral particles after budding within infected cells. RNA viruses such as SARS-CoV-2 use various strategies to disable BST-2. ORF7a TMS interactions play a key role along with extracellular and juxtamembrane domains in modulating BST-2 function (Mann et al. 2023). | Viruses |
Orthornavirae, Pisuviricota | Orf7a of severe acute respiratory syndrome coronavirus 2 |
|
1.C.99.2.3 | X4-like protein of 120 aas and 2 TMSs, N- and C-terminal. | Viruses |
Orthornavirae, Pisuviricota | X4-like protein of Rhinolophus bat coronavirus HKU32 |