1.C.99.2.2
Orf7a of 121 aas and 2 or 3 TMSs, one at the N-terminus, one at the C-terminus, and a peak of moderate hydrophobicity in the middle.  N-terminal fragments of 29 aas, 39 aas and 43 aas can be found in the NCBI protein database (Acc# QIG55990, QIS30140, and QIZ64621, respectively). Bone marrow stromal antigen 2 (BST-2; tetherin) is an antiviral response protein that inhibits transport of viral particles after budding within infected cells. RNA viruses such as SARS-CoV-2 use various strategies to disable BST-2. ORF7a TMS interactions play a key role along with extracellular and juxtamembrane domains in modulating BST-2 function (Mann et al. 2023).