1.D.330. The Chemogenetic Ion Channel (CIC) Family
CICs have several important properties as follows:
- Chemogenetic ion channels are engineered proteins that allow precise control of neuronal activity.
- They respond to specific small molecules, enabling targeted activation or inhibition of neurons.
- These channels can be used to study neural circuits and behavior in live organisms.
- Common examples include DREADDs (Designer Receptors Exclusively Activated by Designer Drugs).
- They offer advantages over traditional methods like optogenetics, including less invasive control.
- Applications span neuroscience research, potential therapeutic strategies, and understanding disease mechanisms.
References: 1. Iguchi et al. 2025; 2. Kolesov et al. 2021; 3. Ozawa and Arakawa 2021; 4. Keifer et al. 2020.
References associated with 1.D.330 family:
Iguchi, Y., R. Benton, and K. Kobayashi. (2025). A chemogenetic technology using insect Ionotropic Receptors to stimulate target cell populations in the mammalian brain. Neurosci Res 214: 56-61. 39532176
Keifer, O., K. Kambara, A. Lau, S. Makinson, and D. Bertrand. (2020). Chemogenetics a robust approach to pharmacology and gene therapy. Biochem Pharmacol 175: 113889. 32119836
Kolesov, D.V., E.L. Sokolinskaya, K.A. Lukyanov, and A.M. Bogdanov. (2021). Molecular Tools for Targeted Control of Nerve Cell Electrical Activity. Part I. Acta Naturae 13: 52-64. 34707897
Ozawa, A. and H. Arakawa. (2021). Chemogenetics drives paradigm change in the investigation of behavioral circuits and neural mechanisms underlying drug action. Behav Brain Res 406: 113234. 33741409