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2.A.1.1.30
Low affinity, constitutive, glucose (hexose; xylose) uniporter, Hxt4 (LGT1; Rag1) (also transports arsenic trioxide [As(OH)3] as do Hxtl, 3, 5, 7 and 9) (Liu et al., 2004).  The Kluyveromyces lactis ortholog is 73% identical and is similarly regulated (Rolland et al. 2006). Key residues for efficient glucose transport by the hexose transporter CgHxt4 in the high sugar fermentation yeast Candida glycerinogenes.have been identified (Qiao et al. 2021).

Accession Number:P32467
Protein Name:Hxt4 aka LGT1 aka RAG1 aka YHR092C
Length:576
Molecular Weight:63910.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate xylose, glucose

Cross database links:

DIP: DIP-7908N
RefSeq: NP_011960.1   
Entrez Gene ID: 856492   
Pfam: PF00083   
KEGG: sce:YHR092C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005624 C:membrane fraction
GO:0005886 C:plasma membrane
GO:0005353 F:fructose transmembrane transporter activity
GO:0005355 F:glucose transmembrane transporter activity
GO:0015578 F:mannose transmembrane transporter activity
GO:0015146 F:pentose transmembrane transporter activity
GO:0008645 P:hexose transport
GO:0055085 P:transmembrane transport

References (5)

[1] “High-copy suppression of glucose transport defects by HXT4 and regulatory elements in the promoters of the HXT genes in Saccharomyces cerevisiae.”  Theodoris G.et.al.   7982576
[2] “Low-affinity glucose carrier gene LGT1 of Saccharomyces cerevisiae, a homologue of the Kluyveromyces lactis RAG1 gene.”  Prior C.et.al.   8154188
[3] “Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.”  Johnston M.et.al.   8091229
[4] “A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.”  Hitchcock A.L.et.al.   14557538
[5] “Xylose transport studies with xylose-utilizing Saccharomyces cerevisiae strains expressing heterologous and homologous permeases.”  Saloheimo A.et.al.   17180689

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSEEAAYQED TAVQNTPADA LSPVESDSNS ALSTPSNKAE RDDMKDFDEN HEESNNYVEI 
61:	PKKPASAYVT VSICCLMVAF GGFVFGWDTG TISGFVAQTD FIRRFGMKHH DGTYYLSKVR 
121:	TGLIVSIFNI GCAIGGIILA KLGDMYGRKM GLIVVVVIYI IGIIIQIASI NKWYQYFIGR 
181:	IISGLGVGGI AVLSPMLISE VSPKHIRGTL VSCYQLMITL GIFLGYCTNY GTKTYTNSVQ 
241:	WRVPLGLGFA WALFMIGGMT FVPESPRYLV EVGKIEEAKR SIALSNKVSA DDPAVMAEVE 
301:	VVQATVEAEK LAGNASWGEI FSTKTKVFQR LIMGAMIQSL QQLTGDNYFF YYGTTVFTAV 
361:	GLEDSFETSI VLGIVNFAST FVGIFLVERY GRRRCLLWGA ASMTACMVVF ASVGVTRLWP 
421:	NGKKNGSSKG AGNCMIVFTC FYLFCFATTW APIPFVVNSE TFPLRVKSKC MAIAQACNWI 
481:	WGFLIGFFTP FISGAIDFYY GYVFMGCLVF SYFYVFFFVP ETKGLTLEEV NTLWEEGVLP 
541:	WKSPSWVPPN KRGTDYNADD LMHDDQPFYK KMFGKK