2.A.117.1.1 The Chlorhexidine drug-resistance exporter, AceI of 179 aas and 4 TMSs (Hassan et al. 2013) . It is capable of exporting multiple drugs such as benzalkonium, dequalinium, proflavine, and acriflavine. (Hassan et al. 2015). The aceI gene is induced in A. baumannii by the short-chain diamines, cadaverine and putrescine. Membrane transport experiments conducted in whole cells of A. baumannii and Escherichia coli and also in proteoliposomes showed that AceI mediates the efflux of
these short-chain diamines (polyamines) such as when energized by an electrochemical
gradient (Hassan et al. 2019), suggesting that they are the phsiological substrates of AceI. AceI can form dimers and is regulated at the transcriptional level by AceR (Bolla et al. 2020).
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Accession Number: | A3M6E6 |
Protein Name: | Putative membrane protein |
Length: | 179 |
Molecular Weight: | 20958.00 |
Species: | Acinetobacter baumannii (strain ATCC 17978 / NCDC KC 755) [400667] |
Number of TMSs: | 4 |
Substrate |
putrescine, cadaverine, 3,6-diaminoacridine, benzalkonium chloride, 3,6-diamino-10-methylacridinium chloride, chlorhexidine |
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1: MINIHLSKKL KEPDWINQNY KNKMHIIQVI IEYLKMLISK RRLIHAISYE GILLVIIAIA
61: LSFIFNMPME VTGTLGVFMA VVSVFWNMIF NHYFEKVEHK YNWERTIPVR ILHAIGFEGG
121: LLIATVPMIA YMMQMTVIDA FILDIGLTLC ILVYTFIFQW CYDHIEDKFF PNAKAASLH