2.A.2.3.14
Probable sugar:cation symporter, MFSD13A or TMEM180, with 517 aas and 12 TMSs with the N- and C-termini reported to be exposed extracellularly (Anzai and Matsumura 2019). It has anti-tumor activity (Yasunaga et al. 2019) and is highly expressed in colorectal cancer (CRC) (Anzai et al. 2021; Shiraishi et al. 2021). It is also a schizophrenia risk factor (Wang et al. 2021).
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| Accession Number: | Q14CX5 |
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| Protein Name: | Transmembrane protein 180 |
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| Length: | 517 |
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| Molecular Weight: | 57381.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 9 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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| Entrez Gene ID: |
79847
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| KEGG: |
hsa:79847
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[1] “The DNA sequence and comparative analysis of human chromosome 10.” Deloukas P. et.al. 15164054
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Team et.al. 15489334
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T. et.al. 14702039
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1: MGLGQPQAWL LGLPTAVVYG SLALFTTILH NVFLLYYVDT FVSVYKINKM AFWVGETVFL
61: LWNSLNDPLF GWLSDRQFLS SQPRSGAGLS SRAVVLARVQ ALGWHGPLLA LSFLAFWVPW
121: APAGLQFLLC LCLYDGFLTL VDLHHHALLA DLALSAHDRT HLNFYCSLFS AAGSLSVFAS
181: YAFWNKEDFS SFRAFCVTLA VSSGLGFLGA TQLLRRRVEA ARKDPGCSGL VVDSGLCGEE
241: LLVGSEEADS ITLGRYLRQL ARHRNFLWFV SMDLVQVFHC HFNSNFFPLF LEHLLSDHIS
301: LSTGSILLGL SYVAPHLNNL YFLSLCRRWG VYAVVRGLFL LKLGLSLLML LAGPDHLSLL
361: CLFIASNRVF TEGTCKLLTL VVTDLVDEDL VLNHRKQAAS ALLFGMVALV TKPGQTFAPL
421: LGTWLLCFYT GHDLFQQSLI TPVGSAHPWP EPPAPAPAQA PTLRQGCFYL LVLVPITCAL
481: LQLFTWSQFT LHGRRLHMVK AQRQNLSQAQ TLDVKMV