2.A.2.3.16
MfsD2B or SLC59A2 protein of 504 aas and 12 TMSs (). It is a cation-dependent lipid transporter that
specifically mediates export of sphingosine-1-phosphate from red blood
cells and platelets (Vu et al. 2017).
Sphingosine-1-phosphate is a signaling sphingolipid, and its export from
red blood cells into in the plasma is required for red blood cell
morphology. It does not transport lysophosphatidylcholine
(LPC).
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| Accession Number: | A6NFX1 |
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| Protein Name: | Major facilitator superfamily domain-containing protein 2B |
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| Length: | 504 |
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| Molecular Weight: | 53743.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
sphingosine 1-phosphate |
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1: MAAPPAPAAK GSPQPEPHAP EPGPGSAKRG REDSRAGRLS FCTKVCYGIG GVPNQIASSA
61: TAFYLQLFLL DIAQIPAAQV SLVLFGGKVS GAAADPVAGF FINRSQRTGS GRLMPWVLGC
121: TPFIALAYFF LWFLPPFTSL RGLWYTTFYC LFQALATFFQ VPYTALTMLL TPCPRERDSA
181: TAYRMTVEMA GTLMGATVHG LIVSGAHRPH RCEATATPGP VTVSPNAAHL YCIAAAVVVV
241: TYPVCISLLC LGVKERPDPS APASGPGLSF LAGLSLTTRH PPYLKLVISF LFISAAVQVE
301: QSYLVLFCTH ASQLHDHVQG LVLTVLVSAV LSTPLWEWVL QRFGKKTSAF GIFAMVPFAI
361: LLAAVPTAPV AYVVAFVSGV SIAVSLLLPW SMLPDVVDDF QLQHRHGPGL ETIFYSSYVF
421: FTKLSGACAL GISTLSLEFS GYKAGVCKQA EEVVVTLKVL IGAVPTCMIL AGLCILMVGS
481: TPKTPSRDAS SRLSLRRRTS YSLA