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2.A.28.1.1
Organic acid/(conjugated) bile acid (taurocholate):Na+ symporter. Taurine conjugates > glycine conjugates > unconjugated bile salts. The initial effect on hepatic bile flow of cholestatic agents such as thorazine and estradiol 17beta-glucuronide are on water flow and not bile salt export pump-mediated bile acid transport (Javitt 2020).

Accession Number:P26435
Protein Name:SLC10A1 aka NTCP
Length:362
Molecular Weight:39295.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate sodium(1+), organic acid, taurocholic acid, taurocholic acid, bile acid taurine conjugate, bile acid glycine conjugate, bile acid

Cross database links:

RefSeq: NP_058743.1   
Entrez Gene ID: 24777   
Pfam: PF01758   
KEGG: rno:24777   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0016021 C:integral to membrane
GO:0008508 F:bile acid:sodium symporter activity
GO:0015721 P:bile acid and bile salt transport
GO:0015711 P:organic anion transport
GO:0006814 P:sodium ion transport

References (2)

[1] “Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system.”  Hagenbuch B.et.al.   1961729
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MEVHNVSAPF NFSLPPGFGH RATDKALSII LVLMLLLIML SLGCTMEFSK IKAHLWKPKG 
61:	VIVALVAQFG IMPLAAFLLG KIFHLSNIEA LAILICGCSP GGNLSNLFTL AMKGDMNLSI 
121:	VMTTCSSFSA LGMMPLLLYV YSKGIYDGDL KDKVPYKGIM ISLVIVLIPC TIGIVLKSKR 
181:	PHYVPYILKG GMIITFLLSV AVTALSVINV GNSIMFVMTP HLLATSSLMP FSGFLMGYIL 
241:	SALFQLNPSC RRTISMETGF QNIQLCSTIL NVTFPPEVIG PLFFFPLLYM IFQLAEGLLI 
301:	IIIFRCYEKI KPPKDQTKIT YKAAATEDAT PAALEKGTHN GNIPPLQPGP SPNGLNSGQM 
361:	AN