3.A.1.205.13
The putative sterol uptake transporter, Aus1. It also protects against antifungal azoles such as fluconazole and itraconazole (Nakayama et al. 2007).
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| Accession Number: | Q6FUR1 |
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| Protein Name: | Uncharacterized protein |
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| Length: | 1398 |
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| Molecular Weight: | 157977.00 |
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| Species: | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) [284593] |
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| Number of TMSs: | 13 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
sterol, 1H-pyrrole, itraconazole, fluconazole |
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1: MSLADYFTPV PNASVTFEGT TVNLNETATG SAHSHAEDPE FGEKLPLPSV SPCENGQVVD
61: LTFQATAGEM VLVLGAPTSG IFKSLFHAHK HLSYSPQGSI RFKDNEFKAY SSKSPHQIIY
121: NNEQDVHFPF LTVNQTVDFA LSCKFDIPKE ERENMRNELL REFGLSHVGD TIVGNDYFRG
181: VSGGERKRIS IIETFIANGS VYLWDNSTKG LDSSTALDFL TILQKMARTT RSVNLVRISQ
241: ASDKIVEKFD KILMLSDSYQ VFYGTVDECL HHFRDNLGIK KDPNDCIIEY LTSILNFQFR
301: TKSLDITGSS EDLDLKDTDH NEQTFSGIAS SLCSEVDLYT QWKKSSYYQD IKEQIGAFNV
361: ENKADGNHIN PEDVTKTFDI PLKKQILYCT KRAFQRSLGD KAYMISQVIS VIIQSLVIGS
421: LFYDIPMTTI GSFSRGSLTF FSILFFTFLS LADMPIAFQR QAVVKKQTLL HFYFNSVETL
481: ATTLFDYCFK FCLVVIFTII LYFLAHLQYN AARFFIFLLF LSVYNFCMVS LFSLTTMFTP
541: TISLANLFAG ILLLAIAMYA SYVIYMKDMH PWFVWIAYLN PAMYAMESIL ANEMFNLKLD
601: CTESVVPRGP TYQNVPVTNK ACAWQGATLG NDYVRGKDYL KNGLSYKYSH VWRNFGILIG
661: FLCFFIAMNL FASEYIKPLF YNDGPEAVQH FINRWFRRSA THSTTSSSSP ENIKLKEDVV
721: VKSASLSSTS SLSSSETAKS NPFADKTVQA QKHVISWKNI NYTVGGDKRL INNVSGYIGS
781: GLTALMGESG AGKTTLLNVL SQRTESGVVS GEILIDGKPL TNENAFRRSI GFVQQQDIHL
841: ELLTVKESLE ISSELRGDGD MEYVESISEL LKLPLDSLVR ELNPTQRKLL SIGVELVTKP
901: SLLLFLDEPT SGLDAEAALT IVQFLKKLSL QGQAIFCTIH QPSKSVISYF DNIYLLKRGG
961: ECVYFGPTSE ACGYFMSYDK SLTYDPESDN PADFVIDVVG NNESMEEMDD KADFAIREEN
1021: PWSTRWENSH ERKNIDETVV RLEQEAAASG VDFTTAVWEQ PSYMKQLIMI TKRQYTCTRR
1081: DRSYIAAKYL LNGGAGLFIG FSFWKIKHTI SGLQDTIFFC FMALCVSSPL INQVQDKALQ
1141: SKEVFIARES RSNTYHWTCL LLAQFIIELP LAMSSSTLFF VCAFFCCGFD NSGKVAGVFY
1201: LNYILFSAYY LTLGLWLIYT APNLQTAAVF VAFIYSFTAS FCGVMQPYAL FPGFWKFMYR
1261: VSPYTYFVDT FVSTLLHNRK VICNTGEMVP GQPTGGKTCG QFFKAYIDEY GGWLKNPNTF
1321: TVCAYCTYDT GDDFLKQQNM SHSHIWRNYG IEWAFVAFNF FAMFAGYYLT YVAKVWPKVF
1381: KFIMKLIPTG IKSRASKD