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TCID	Name	Domain	Kingdom/Phylum	Protein(s)
4.D.2.1.1	UPF0104 of 340 aas and 8 putative TMSs	Archaea	Euryarchaeota	UPF0104 of Methanococcoides burtonii (Q12TG6)
4.D.2.1.2	Nitrogenase molybdenum-iron (NMI) α and β chain-like protein of 347aas and 10 putative TMSs	Archaea	Euryarchaeota	NMI-like protein of Methanocorpusculum labreanum Z (A2SSY9)
4.D.2.1.3	Lysyl phosphatidyl glycerol synthetase	Archaea	Euryarchaeota	Lysyl-PG synthetase of Archaeoglobus veneficus (F2KRG7)
4.D.2.1.4	TerC of 326aas and 10 TMSs	Bacteria	Bacillota	TerC of Selenomonas sp. oral taxon 149 (E0NY51)
4.D.2.1.5	Putative ABC transporter (348 aas; 8 TMSs)	Bacteria	Bacillota	Putative ABC transporter of Eubacterium yurii (E0QJ98)
4.D.2.1.6	Putative family 2 glycosyl transferase (538 aas; 8 putative TMSs), This protein is designated DPG synthase. Residues 1-220 are in the COGO392 or UPF0108 superfamily while residues 221-538 are in the lysyl phosphatidyl glycerol synthetase domain family). The N-terminal domain of 3.A.3.4.3 (e^-8) and an N-terminal domain of 4.D.1.1.3 (e^-5) are part of the MFS, but the common domain in TC family 4.D.2 is the lysyl phosphatidyl glycerol synthetase domain.	Archaea	Euryarchaeota	ORF of Archaeoglobus veneficus (F2KQZ0)
4.D.2.1.7	Putative transporter of 348 aas and 8 TMSs. Is encoded together with and probably functions with the ABC transporter TC# 3.A.1.147.6.	Bacteria	Bacillota	Putaqtive transporter of Clostridium difficile
4.D.2.1.8	UPF0104 family protein of 387 aas and 7 TMSs.	Bacteria	Mycoplasmatota	UPF0104 protein of Ureaplasma parvum
4.D.2.1.9	Glycosyl transferase family 2 (GT2; N-terminal) - GtrA 4 TMS domain (C-terminal) protein of 384 aas and 4 - 7 TMSs.	Bacteria	Candidatus Zambryskibacteria	GT2-GtrA protein of Candidatus Zambryskibacteria bacterium
4.D.2.1.10	UPF0104 family protein of 345 aas and 9 or 10 TMSs, in a 5 or 6 + 4 TMS arrangement. Shows extensive similarity to the MFS domains of TC# 3.A.3.4.3 and 4.H.1.2.1.	Bacteria	Chloroflexota	UPF0104 protein of Chloroflexi bacterium
4.D.2.2.1	Uncharacterized protein of 344 aas with 1 N-terminal TMS and 3 C-terminal TMSs.	Archaea	Euryarchaeota	HP of Haloarcula marismotui (Q5UXW9)
4.D.2.2.2	Pych_15620 (330aas; 8 TMSs) (Most resembles 4.D.2.2.1 and 4.D.2.1.2).	Archaea	Euryarchaeota	Pych_15620 of Pyrococcus yayanosii (F8AGU2)
4.D.2.2.3	Uncharacterized protein of 331 aas and 8 TMSs.	Bacteria	Bdellovibrionota	UP of Bdellovibrio bacteriovorus
4.D.2.2.4	Uncharacterized protein of 335 aas and 8 probable TMSs in a 2 + 2 + 4 arrangement.	Archaea	Euryarchaeota	UP of Methanobacterium subterraneum
4.D.2.2.5	Uncharacterized flippase-like domain-containing protein of 243 aas and 8 TM	Archaea	Euryarchaeota	UP of Thermococcus sp. 4557
4.D.2.3.1	Sros_7630 (353aas; 8-9 TMSs) (UPF0164 Superfamily)	Bacteria	Actinomycetota	Sros_7630 of Streptosporangium roseum (D2ARG4)
4.D.2.4.1	Rv0204c (412aas; 8 putative TMSs). May be part of a heme iron acquisition system (Tullius et al. 2011).	Bacteria	Actinomycetota	Rv0204c of Mycobacterium tuberculosis (O53655)
4.D.2.4.2	Varpa_1810 (335aas; 8 TMSs) (TMSs 1-7 resemble TMSs 1-7 of 2.A.1.3.47) (e^-10) and 2.A.1.3.44 (e^-9) of the MFS).	Bacteria	Pseudomonadota	Varpa_1810 of Variovorax paradoxus (E6V6R4)
4.D.2.4.3	YbhN of 318 aas and 8 TMSs	Bacteria	Pseudomonadota	YbhN of E. coli
4.D.2.4.4	Uncharaterized protein of 377 aas and 8 TMSs.	Bacteria	Actinomycetota	UP of Acidithrix ferrooxidans
4.D.2.5.1	Cagg_0771 (348aas; 8 TMSs). Shows extensive sequence similarity to 3.A.3.4.3 (N-terminal 300aas; first ~8 TMSs before the ATPase domain) and 2.A.1.3.43 (C-terminal 300aas; last 8 TMSs).	Bacteria	Chloroflexota	Cagg_0771 of Chloroflexus aggregans (B8G562)
4.D.2.5.2	Osct_1517 (341aas; 8 TMSs in a 5+3 arrangement like several of those cited above). (Resembles 4.D.2.1.3 and 6 in addition to 3.A.3.4.3 and 2.A.1.3.43)	Bacteria	Chloroflexota	Osct_1517 of Oscillochloris trichoides (E1IDW6)
4.D.2.5.3	Flippase-like domain-containing protein of 370 aas and 8 TMSs in a 5 + 3 TMS arrangement.	Bacteria	Chloroflexota	Flippase of Anaerolinea thermophila