| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.133.1.1 | Siah-1 of 282 aas. It plays roles in the stability and degradation of many proteins (Czechowicz et al. 2018). These include polycystin-1, TrpVs and several other transporters (see family description). | Eukaryota |
Metazoa, Chordata | Siah-1 on Homo sapiens |
|
8.A.133.1.2 | Siah-2 of 324 aas. Seven in absentia homologue-2 (Siah-2) is a host protein that can act as does Siah-1, but with different protein specificities. It mediates the ubiquitination of proteins and is known for its interaction with them to alter their stabilities as affect several cell functions (Malz et al. 2012). | Eukaryota |
Metazoa, Chordata | Siah-2 of Homo sapiens |
|
8.A.133.1.3 | E3 ubiquitin-protein ligase SINA-like 9 of 345 aa | Eukaryota |
Viridiplantae, Streptophyta | SINA-like 9 protein of Elaeis guineensis (African oil palm) |
|
8.A.133.1.4 | E3 ubiquitin-protein ligase SINA-like 11 protein of 386 aas and 1 TMS. | Eukaryota |
Viridiplantae, Streptophyta | SINA-like protein of Oryza sativa Japonica Group (Japanese rice) |
|
8.A.133.1.5 | Uncharacterized protein of 270 aas and 2 closely spaced TMSs between residues 66 and 106. | Eukaryota |
Metazoa, Chordata | UP of Xenopus tropicalis (tropical clawed frog) |
|
8.A.133.1.6 | Uncharacterized protein of 281 aas and 2 possible TMSs. | Eukaryota |
Oomycota | UP of Aphanomyces euteiches |
|
8.A.133.1.7 | Uncharacterized protein of 366 aas and possibly 2 TMSs. | Eukaryota |
Haptophyta | UP of Emiliania huxleyi |
|
8.A.133.1.8 | E3 ubiquitin-protein ligase RNF114 of 222 aas and maybe 2 N-terminal TM | Eukaryota |
Metazoa, Chordata | Ubiuitin ligase of Microcaecilia unicolor |
|
8.A.133.1.9 | Uncharacterized protein of 291 aas and 1 or 2 possible N-terminal TMS(s). | Eukaryota |
Fungi, Basidiomycota | UP of Rhodotorula toruloides |
|
8.A.133.1.10 | Uncharacterized protein of 596 aas and 4 C-terminal TMSs in a 2 + 2 TMS arrangement. | Eukaryota |
Bacillariophyta | UP of Fragilariopsis cylindrus |
|
8.A.133.1.11 | TNF receptor-associated factor 4, TRAF4, of 470 aas and 0 TMSs. It is an adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, platelet activation and apoptosis (Cai et al. 2018). It ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain, leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation (Li et al. 2019). It has an N-terminal domain similar to those of members of this family, but it has a C-terminal domain similar to sheddases such as that in TC# 8.A.77.2.1. | Eukaryota |
Metazoa, Chordata | TRAF4 of Homo sapiens |
|
8.A.133.1.12 | Tumor necrosis factor receptor 6 of 681 aas and 0 TMSs. TRAF6 is a key molecular link in the TNF superfamily. Zhang et al. 2024 conducted a series of studies targeting the TRAF6 gene. | Eukaryota |
Metazoa, Mollusca | TRAF6 of Argopecten irradians |
|
8.A.133.1.13 | E3 ubiquitin-protein ligase, TRIM7, that have both tumor-promoting and tumor-suppressing activities and functions in several biological processes including innate immunity, regulation of ferroptosis as well as cell proliferation and migration (Fan et al. 2021). It also acts as an antiviral effector against multiple viruses by targeting specific viral proteins for ubiquitination and degradation including norovirus NTPase protein or SARS-CoV-2 NSP5 and NSP8 proteins (Liang et al. 2022). TRIM7 suppresses the tumorigenesis of gastric cancer by targeting the SLC7A11 cystine/glutamate amino acid transporter (Chen et al. 2024). Targeting Zfp36 (mRNA decay activator protein) combats cardiac hypertrophy and provides insight into ferroptosis pathways (Zhang et al. 2025). | Eukaryota |
Metazoa, Chordata | TRM7 of Homo sapiens |