8.A.133.1.2
Siah-2 of 324 aas. Seven in absentia homologue-2 (Siah-2) is a host protein that can act as does Siah-1, but with different protein specificities. It mediates the ubiquitination of proteins and is known for its interaction with them to alter their stabilities as affect several cell functions (Malz et al. 2012).
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| Accession Number: | O43255 |
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| Protein Name: | E3 ubiquitin-protein ligase SIAH2 |
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| Length: | 324 |
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| Molecular Weight: | 34615.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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1: MSRPSSTGPS ANKPCSKQPP PQPQHTPSPA APPAAATISA AGPGSSAVPA AAAVISGPGG
61: GGGAGPVSPQ HHELTSLFEC PVCFDYVLPP ILQCQAGHLV CNQCRQKLSC CPTCRGALTP
121: SIRNLAMEKV ASAVLFPCKY ATTGCSLTLH HTEKPEHEDI CEYRPYSCPC PGASCKWQGS
181: LEAVMSHLMH AHKSITTLQG EDIVFLATDI NLPGAVDWVM MQSCFGHHFM LVLEKQEKYE
241: GHQQFFAIVL LIGTRKQAEN FAYRLELNGN RRRLTWEATP RSIHDGVAAA IMNSDCLVFD
301: TAIAHLFADN GNLGINVTIS TCCP