8.A.143.1.5
TMEM132e of 1074 aas and 2 TMSs. Ion channel function for the α9α10 nicotinic acetylcholine receptor (1.A.9.1.22) requires an auxiliary subunit, which
can be transmembrane inner ear (TMIE; TC# 8.A,116) or TMEM132e. Both of these
single-pass transmembrane proteins are enriched in hair cells and
underlie nonsyndromic human deafness (Gu et al. 2020).
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| Accession Number: | Q6IEE7 |
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| Protein Name: | Transmembrane protein 132E |
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| Length: | 1074 |
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| Molecular Weight: | 116150.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MAPGMSGRGG AALLCLSALL AHASGRSHPA SPSPPGPQAS PVLPVSYRLS HTRLAFFLRE
61: ARPPSPAVAN SSLQRSEPFV VFQTKELPVL NVSLGPFSTS QVVARELLQP SSTLDIPERL
121: TVNWKVRAFI VRSHVPASQP VVQVLFYVAG RDWDDFGVTE RLPCVRLHAF RDAREVKSSC
181: RLSGGLATCL VRAELPLAWF GPPAPAAPPT ARRKSPDGLE PEATGESQQA ELYYTLHAPD
241: ASGGCGGSRR GAGPGVGARA ESPTQHPLLR IGSISLFRPP PRRTLQEHRL DSNLMIRLPD
301: RPLKPGEVLS ILLYLAPNSS SPSSPSVEHF TLRVKAKKGV TLLGTKSRSG QWHVTSELLT
361: GAKHSTATVD VAWAQSTPLP PREGQGPLEI LQLDFEMENF TSQSVKRRIM WHIDYRGHGA
421: LPDLERAVTE LTVIQRDVQA ILPLAMDTEI INTAILTGRT VAIPVKVIAI EVNGLVLDIS
481: ALVECESDNE DIIKVSSSCD YVFVSGKESR GSMNARVTFR YDVLNAPLEM TVWVPKLPLH
541: IELSDARLSQ VKGWRVPILP DRRSVRESED EDEEEEERRQ SASRGCTLQY QHATLQVFTQ
601: FHTTSSEGTD QVVTMLGPDW LVEVTDLVSD FMRVGDPRVA HMVDSSTLAG LEPGTTPFKV
661: VSPLTEAVLG ETLLTVTEEK VSITQLQAQV VASLALSLRP SPGSSHTILA TTAAQQTLSF
721: LKQEALLSLW LSYSDGTTAP LSLYSPRDYG LLVSSLDEHV ATVTQDRAFP LVVAEAEGSG
781: ELLRAELTIA ESCQKTKRKS VLATTPVGLR VHFGRDEEDP TYDYPGPSQP GPGGGEDEAR
841: GAGPPGSALP APEAPGPGTA SPVVPPTEDF LPLPTGFLQV PRGLTDLEIG MYALLGVFCL
901: AILVFLINCI VFVLRYRHKR IPPEGQTSMD HSHHWVFLGN GQPLRVQGEL SPPAGNPLET
961: VPAFCHGDHH SSGSSQTSVQ SQVHGRGDGS SGGSARDQAE DPASSPTSKR KRVKFTTFTT
1021: LPSEELAYDS VPAGEEDEEE EEDLGWGCPD VAGPTRPTAP PDLHNYMRRI KEIA