8.A.179.1.1
Nicotinic Acetylcholine Receptor Regulator (NACHO; TMEM35A) of 167 aas and 4 TMSs in a 1 + 3 TMS arrangement (Loring 2022). It is a molecular
chaperone that mediates the proper assembly and functional expression
of nicotinic acetylcholine receptors (nAChRs) throughout the brain
(Gu et al. 2016, Rex et al. 2017, Kweon et al. 2020). Inhibition of AMPA receptors (AMPARs, e.g., TC# 1.A.10.1.1) containing
transmembrane AMPAR regulatory protein gamma-8 (TC# 8.A.61.1.10) with
JNJ-55511118 (TC#8.A.179.1.1; NACHO) shows preclinical efficacy in reducing
chronic repetitive alcohol self-administration (Hoffman et al. 2021). See the family description for more details. TMEM35A mediates the transmembrane transport of Epicatechin (EC), and the interaction between TMEM35A and TMPO inhibits the MAPK and NF-kappaB pathways (Ma et al. 2021).
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| Accession Number: | Q53FP2 |
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| Protein Name: | Novel acetylcholine receptor chaperone |
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| Length: | 167 |
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| Molecular Weight: | 18440.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 3 |
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| Location1 / Topology2 / Orientation3: |
Peroxisome membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MASPRTVTIV ALSVALGLFF VFMGTIKLTP RLSKDAYSEM KRAYKSYVRA LPLLKKMGIN
61: SILLRKSIGA LEVACGIVMT LVPGRPKDVA NFFLLLLVLA VLFFHQLVGD PLKRYAHALV
121: FGILLTCRLL IARKPEDRSS EKKPLPGNAE EQPSLYEKAP QGKVKVS