8.A.180. The Retinol-binding protein (RBP) Family
RBP4 mediates retinol transport in blood plasma (Peterson 1971). It delivers retinol from the liver stores to the peripheral tissues and transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (Berry et al. 2012). It is a small molecule transporter (Xiong et al. 2021).
This family belongs to the: Protease Inhibitor-like (PI-l) Superfamily.
References associated with 8.A.180 family:
Berry, D.C., S.M. O''Byrne, A.C. Vreeland, W.S. Blaner, and N. Noy. (2012). Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6. Mol. Cell Biol. 32: 3164-3175. 22665496
Peterson, P.A. (1971). Studies on the interaction between prealbumin, retinol-binding protein, and vitamin A. J. Biol. Chem. 246: 44-49. 5541771
Xiong, S., T. Qi, N. Gong, and C. Yang. (2021). Correlation and Diagnostic Value of Serum RBP4 and sRAGE and the Condition of Patients with Chronic Kidney Disease. Evid Based Complement Alternat Med 2021: 6166528. 34745291