8.A.23.1.68
Cell adhesion molecule 1, isoform A, CADM1 (TSLC-1; nectin-like protein 2) of 471 aas and 2 TMSs, N- and C-terminal. It regulates PIEZO1 (Koster et al. 2024). CADM1/SynCAM slows the inactivation kinetics
of PIEZO1 with little effect on PIEZO2. Conversely, CADM1
knockdown accelerates inactivation of endogenous PIEZO1 in Neuro-2a
cells. Systematic deletion of CADM1 domains indicates that the
transmembrane region is critical for the observed effects on PIEZO1,
suggesting that modulation of inactivation is mediated by interactions
in or near the lipid bilayer (Koster et al. 2024).
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| Accession Number: | Q8R5M8 |
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| Protein Name: | Cell adhesion molecule 1 |
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| Length: | 456 |
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| Molecular Weight: | 49788.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MASAVLPSGS QCAAAAAVAA AAAPPGLRLR LLLLLLSAAA LIPTGDGQNL FTKDVTVIEG
61: EVATISCQVN KSDDSVIQLL NPNRQTIYFR DFRPLKDSRF QLLNFSSSEL KVSLTNVSIS
121: DEGRYFCQLY TDPPQESYTT ITVLVPPRNL MIDIQKDTAV EGEEIEVNCT AMASKPATTI
181: RWFKGNKELK GKSEVEEWSD MYTVTSQLML KVHKEDDGVP VICQVEHPAV TGNLQTQRYL
241: EVQYKPQVHI QMTYPLQGLT REGDAFELTC EAIGKPQPVM VTWVRVDDEM PQHAVLSGPN
301: LFINNLNKTD NGTYRCEASN IVGKAHSDYM LYVYDPPTTI PPPTTTTTTT TTTTTTILTI
361: ITDTTATTEP AVHDSRAGEE GTIGAVDHAV IGGVVAVVVF AMLCLLIILG RYFARHKGTY
421: FTHEAKGADD AADADTAIIN AEGGQNNSEE KKEYFI