8.A.23.1.8
Neuroplastin NptN of 398 aas (Beesley et al. 2014). Important for targetting of certain transporters such as Xkr8 to the plasma membrane with which it, with basigin, forms a physical complex (Suzuki et al. 2016). Neuroplastin expression is essential for hearing and hair cell PMCA (TC# 3.A.3.2.40) expression (Lin et al. 2021). Mice lacking expression of neuroplastin (Np), a type-1 transmembrane
glycoprotein, display deafness, multiple cognitive deficiencies, and
reduced expression of plasma membrane calcium (Ca2+) ATPases (PMCAs) in cochlear hair cells and brain neurons (Liang et al. 2024).
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| Accession Number: | Q9Y639 |
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| Protein Name: | Neuroplastin |
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| Length: | 398 |
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| Molecular Weight: | 44387.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MSGSSLPSAL ALSLLLVSGS LLPGPGAAQN AGFVKSPMSE TKLTGDAFEL YCDVVGSPTP
61: EIQWWYAEVN RAESFRQLWD GARKRRVTVN TAYGSNGVSV LRITRLTLED SGTYECRASN
121: DPKRNDLRQN PSITWIRAQA TISVLQKPRI VTSEEVIIRD SPVLPVTLQC NLTSSSHTLT
181: YSYWTKNGVE LSATRKNASN MEYRINKPRA EDSGEYHCVY HFVSAPKANA TIEVKAAPDI
241: TGHKRSENKN EGQDATMYCK SVGYPHPDWI WRKKENGMPM DIVNTSGRFF IINKENYTEL
301: NIVNLQITED PGEYECNATN AIGSASVVTV LRVRSHLAPL WPFLGILAEI IILVVIIVVY
361: EKRKRPDEVP DDDEPAGPMK TNSTNNHKDK NLRQRNTN