| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.245.1.1 | VEGFA of 395 aas with two possible TMSs at residies 50 and 190. It induces permeabilization of blood vessels while preventing the downregulation of KCC2 induced by axotomy in extraocular motoneurons (Capilla-López et al. 2024). | Eukaryota |
Metazoa, Chordata | VEGFA of Homo sapiens |
|
8.A.245.1.2 | Vascular endothelial growth factor B, VEGFB, of 207 aas with 1 N-terminal TMS, and possibly one at residue 60. It is a growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. | Eukaryota |
Metazoa, Chordata | VEGFB of Homo sapiens |
|
8.A.245.1.3 | Vascular endothelial growth factor C (4), VEGF4, of 419aas and 1 N-terminal TMS. It is a growth factor active in angiogenesis as well as endothelial cell growth, stimulating their proliferation and migration. It also has effects on the permeability of blood vessels, and may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. It also plays a role in the maintenance of differentiated lymphatic endothelium in adults, and binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. | Eukaryota |
Metazoa, Chordata | VEGFC of Homo sapiens (P49767) |
|
8.A.245.1.4 | VEGFD of 354 aas and 1 N-terminal TMS. It binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors (Leppänen et al. 2011). | Eukaryota |
Metazoa, Chordata | VEGFD of Homo sapiens |